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Öğe A comprehensive review on the usability of black phosphorus in energy and wastewater treatment(Elsevier Inc., 2024) Kaya, Gul; Eskikaya, Ozan; Kucukosman, Ridvan; Ocakoglu, Kasim; Dizge, Nadir; Balakrishnan, Deepanraj; Singh Chohan, JasgurpreetIncreasing population and industrial development brings with it many problems that need to be solved, such as energy production, storage, saving, protection of limited reserves, and environmental pollution. Nanomaterials, which emerged with the introduction of nanotechnology into our lives, play an important role in many areas. The novel two-dimensional nanomaterial black phosphorus (BP) exhibits great potential in photocatalytic applications, energy technologies, and purification with properties such as broad light absorption spectrum, tunable direct band gap, and exceptionally high charge carrier mobility. This review gives a outline of the manufacturing techniques, structural, chemical, electrical and thermal properties of BP. Then, the success of BP derivatives with different dimensions and morphologies in environmental and energy applications is presented by comparing them with previous studies in these fields. The results show that heterojunction structures produced by combining BP with MoS2 and MOFs improve the electrochemical properties of BP, while carbonization processes increase its efficiency in battery and supercapacitor applications. Finally, in this review, a summary of BP's potential future uses, awareness of easy production methods, and its activities in environmental and energy applications are discussed in a broad context. © 2024Öğe A Cr2AlC MAX Phase-Based Electrochemical Probe for the Detection of Asciminib in Biological and Pharmaceutical Samples(Wiley-V C H Verlag Gmbh, 2025) Genc, Asena Ayse; Bouali, Wiem; Erk, Nevin; Kaya, Gul; Ocakoglu, KasimThe Cr2AlC MAX phase, a two-dimensional transition metal carbide, offers a compelling combination of properties ideal for electrochemical sensor fabrication. The exceptional electrical conductivity, high surface area, and inherent electrocatalytic activity of the catalyst enable the sensitive and selective detection of diverse analytes, including biomolecules of critical clinical relevance. This work presents the construction of a novel electrochemical sensor featuring a nanoscale Cr2AlC MAX phase-modified electrode, demonstrating its exceptional analytical performance in Asciminib detection, a crucial aspect of chronic myeloid leukemia (CML) treatment. The sensor exhibits a low limit of detection (0.212 mu M) and a low limit of quantification (0.698 mu M) and demonstrates excellent sensitivity toward Asciminib in the linear range of 1 mu M-10 mu M. Moreover, a rigorous tolerance limit has been established, allowing the sensor to tolerate the highest concentration of interfering substances with an error of less than +/- 5% in determining ASC current. Successful quantification of Asciminibin biological samples further validates the method's reliability for real-world applications. This novel electrochemical approach provides a rapid and cost-effective alternative to existing methods and contributes significantly to the nanomaterial-enabled advancement of CML management, ensuring precise Asciminib quantification at the nanoscale.Öğe Antioxidant activity, DNA cleavage ability, and antibacterial properties of ceramic membrane coated with cobalt nanoparticles(Elsevier Ltd, 2025) Belibagli, Pinar; Dogan, Ali Can; Kaya, Gul; Dizge, Nadir; Ocakoglu, Kasim; Özdemir, Sadin; Tollu, GülsahCeramic membranes are increasingly used in water/wastewater treatment due to their excellent filtration/separation performance, mechanical, thermal and long-term stability. In this study, ceramic clay membranes coated with cobalt nanoparticles (Co NP) were produced to increase the antibacterial properties of ceramic membranes produced using clay, a natural and cost-effective material. The morphological structure of Co NP ceramic clay membranes was determined by SEM analysis and the surface of the ceramic clay membrane coated with Co NP gained a smooth surface feature close to homogeneity. The antioxidant activity of CoNPs was 69.26 % at 100 mg/L. Plasmid DNA was entirely degraded at 50 mg/L nanoparticle concentrations. At a concentration of 100 mg/L, α-amylase inhibition of 86.39 % was exhibited by the CoNPs solution. CoNPs exhibited significant antimicrobial activities against L. pneumophila subsp. pneumophila, E. hirae, and E. faecalis (Minimum Inhibition concentration (MIC):16 mg/L). The cell viability inhibitory effect of the NPs was 98.27 % at 20 mg/L concentration against E. coli. The antibiofilm activities of the CoNPs were determined 82.13 % and 71.67 % against S. aureus and P. aeruginosa, respectively. Furthermore, the E. coli elimination performance of CoNP coated on the solid surface of the ceramic membrane was obtained as 94.64 %. In line with all these results, it has been clearly proven that Co NP ceramic clay membranes can be used in water and wastewater treatment due to their convenient, cheap, and effective antibacterial properties. © 2024 Elsevier Ltd and Techna Group S.r.l.Öğe Development of a Cr2AlC MAX phase/g-C3N4 composite-based electrochemical sensor for accurate cabotegravir determination in pharmaceutical and biological samples(Springer, 2024) Bouali, Wiem; Genc, Asena Ayse; Erk, Nevin; Kaya, Gul; Sert, Buse; Ocakoğlu, KasımA highly sensitive electrochemical sensor is reported that employs a modified electrode for the precise measurement of cabotegravir, a potent anti-HIV drug. Cyclic voltammetry (CV), differential pulse voltammetry (DPV), and electrochemical impedance spectroscopy (EIS) were utilized for this purpose. Electrode modification involved the immobilization of Cr2AlC MAX phase/g-C3N4 onto a glassy carbon electrode (GCE) to enhance its electrocatalytic activity and selectivity for cabotegravir detection. Under the optimal experimental conditions, the working potential (vs. Ag/AgCl) was to 0.93 V. The developed sensor exhibited a good linear relationship in the range 0.05 µM to 9.34 µM with a low limit of detection of 4.33 nM, signifying its exceptional sensitivity. Additionally, it demonstrated successful cabotegravir detection in pharmaceutical formulations and biological samples, achieving an RSD below 3.0%. The recoveries fell within the range 97.7 to 102%, confirming the sensor's potential for real-sample applications. This innovative electrochemical sensor represents a significant advancement, providing a simple, reliable, and sensitive tool for the accurate measurement of cabotegravir. Its potential applications include optimizing drug dosages, monitoring treatment responses, and supporting the development of cabotegravir-based pharmaceutical products, thereby contributing to advancements in HIV therapy and prevention strategies.Öğe Influence of silane coating and graphene oxide integration on the magnetothermal Behaviors of La1-xSrxMnO3 nanoparticles(Elsevier, 2025) Sert, Buse; Kaya, Gul; Cicek, Sinem; Harputlu, Ersan; Simsek, Telem; Tekgul, Atakan; Unlu, C. GokhanIn this study, La1-xSrxMnO3 (x = 0.27, 0.3, 0.33) magnetic nanoparticles (MNPs) were synthesized and then these nanoparticles synthesized in the core-shell structure were coated with silane for potential magnetic hyperthermia applications. In order to provide support material for the coated magnetic nanoparticles, silane-coated hybrid magnetic nanoparticles were obtained by producing graphene oxide (GO) nanoflakes. The structural and magnetic properties and magnetothermal properties of these structures were investigated. It was observed that the structure of the silane-coated magnetic nanoparticles remained intact and did not show any degradation compared to the uncoated materials. In addition, the highest saturation magnetization (MS) value was observed in the sample doped with x = 0.30. This value indicated that the heating power would be higher than the other doped samples in the specific absorption ratio (SAR) measurements. In this context, the heating amount in the silane-coated samples showed a slight decrease compared to the uncoated samples. Despite the decrease in the SAR values of the integrated samples by incorporating GO into the coated MNPs, it is anticipated that effective results will be obtained for practical applications with the advantage of increasing the thermal conductivity of GO.Öğe Investigating the effect of coating and synthesis parameters on La1-xSrxMnO3 based core-shell magnetic nanoparticles(Elsevier, 2025) Sert, Buse; Kaya, Gul; Tataroglu, Aleyna Akcay; Harputlu, Ersan; Simsek, Telem; Tekguel, Atakan; Unlu, C. GokhanMagnetic nanoparticles are an important class of functional materials that have unique magnetic properties due to their reduced size (<100 nm) and have the potential for use in many fields. In the preparation of magnetic nanoparticles, factors such as intrinsic magnetic properties, surface coating, size and shape of the particles, surface charge and stability are very important. In this regard, carefully determining the synthesis parameters of magnetic nanoparticles and particle coating materials is of critical importance in the application area chosen for the material. In this study, La1-xSrxMnO3 (x = 0.27, 0.30, 0.33) magnetic nanoparticles (MNPs), carbon-coated magnetic nanoparticles in core-shell structure (C@MNP) and their derivatives integrated into graphene oxide (GO-C@MNP) were synthesized and their properties were investigated in detail for their use in possible future application studies. The crystal structure of perovskite compounds with Pbnm symmetry remains unchanged after carbon coating but shrinks in volume due to its amorphous structure. The magnetic behavior of the uncoated and coated materials is almost identical, but the Curie temperature of the compounds shifts to a higher temperature. In the specific absorption ratio (SAR) measurements performed, it was found that the best SAR value for carbon-coated MNPs was 12.9 W/g at x = 0.27. By integrating the MNPs into graphene oxide, heat is easily distributed regionally, and this shows that the structures can be ideal candidates for applications such as hyperthermia, drug carriers, tissue repair, and cellular therapy including cell labeling and targeting. Perovskite-structured manganite materials were selected for their suitability in controlled production, where the Curie temperature can be tuned near the therapeutic temperature by adjusting the doping levels, making them ideal for magnetic hyperthermia applications. In this study, for the first time, the nanoparticle surfaces were coated with carbon, which was chosen not only due to carbon's non-magnetic nature but also because it provides an ideal platform for future combined biomedical applications such as drug delivery systems.Öğe Photothermal and photodynamic responses of core-shell Mo2C@C@Fucoidan nanospheres(Elsevier Science Sa, 2025) Tuncel, Ayca; Sert, Buse; Ozel, Derya; Kaya, Gul; Harputlu, Ersan; Unlu, Cumhur Gokhan; Ocakoglu, KasimMo2C structure, a transition metal carbide, is known for its exceptional properties including high chemical and thermal stability and surface activity. Recently, carbon-modified Mo2C structures have found widespread applications due to their effectiveness. Here, we synthesized pomegranate-like Mo2C@C nanospheres and coated them with poly(allylamine hydrochloride) (PAH) and fucoidan structures. Characterization techniques including FE-SEM, HR-TEM, XRD, XPS, and zeta potential analysis were employed. We investigated the effect of Mo2C@C@Fuc nanospheres by quantitatively evaluating their photothermal conversion efficiency. Under irradiation at wavelengths of 808 nm and 1064 nm with a power intensity of 2 W/cm2, these nanospheres could convert up to 15 % of the incident laser energy into heat, outperforming conventional materials. Stability tests in various physiological pH environments confirmed their durability under NIR irradiation, ensuring operational integrity in biological environments. In addition, they showed significant efficiency in the production of singlet oxygen, making them promising agents for PDT. Biodegradation studies indicated safe degradation after ther- apeutic application, highlighting their environmental and physiological compatibility. Integrating Mo2C@C@- Fuc nanospheres into anticancer strategies combines the advantages of PTT and PDT, promising improved therapeutic outcomes with high biocompatibility.Öğe Synthesis of PES membranes modified with polyurethane–paraffin wax nanocapsules and performance of bovine serum albumin and humic acid rejection(IWA Publishing, 2023) Sert, Buse; Kaya, Gul; Ozay, Yasin; Alterkaoui, Aya; Ocakoglu, Kasım; Dizge, NadirMembrane fouling is a serious handicap of membrane-based separation, as it reduces permeation flux and hence increases operational and maintenance expenses. Polyurethane–paraffin wax (PU/PW) nanocapsules were integrated into the polyethersulfone membrane to manufacture a composite membrane with higher antifouling and permeability performance against humic acid (HA) and bovine serum albumin (BSA) foulants. All manufactured membranes were characterized by scanning electron microscopy (SEM), scanning electron microscopy-energy dispersive spectrometry (SEM-EDS), and contact angle. The contact angle of the pristine polyethersulfone (PES) membrane was measured 73.40 + 1.32. With the embedding of nanocapsules, the contact angle decreased to 64.55 + 1.23 for PES/PU/PW 2.0 wt%, and the pure water flux of all composite membranes increased when compared to pristine PES. The pristine PES membrane also has shown the lowest steady-state fluxes at 45.84 and 46.59 L/m2 h for BSA and HA, respectively. With the increase of PU/PW nanocapsule ratio from 0.5 to 1.0 wt%, steady-state fluxes increased from 51.96 to 71.61 and from 67.87 to 98.73 L/m2 h, respectively, for BSA and HA. The results depicted that BSA and HA rejection efficiencies of PU/PW nanocapsules blended PES membranes increased when compared to pristine PES membranesÖğe Synthesis, characterization and evaluation of the photochemical properties and photothermal conversion capacities of Mo2CTx-MXene@Fuc nanohybrids(Elsevier Science Sa, 2025) Yurt, Fatma; Tuncel, Ayca; Kaya, Gul; Sert, Buse; Ozel, Derya; Harputlu, Ersan; Unlu, Cumhur GokhanStudies on synthesizing MXene hybrid materials continue in medicine, biomedicine, the environment, electronics, and many other fields. MXenes are very remarkable materials for diagnosis, treatment, and theranostic applications in oncology with their hydrophilic structure, large surface area, and biocompatibility. In this study, MAX phase and Mo2CTx MXene syntheses were first carried out and characterized by XRD and HR-TEM. Then, PAH and fucoidan were coated on the MXene surface, respectively, and characterized by FE-SEM, XPS, and Zeta potential methods. Experiments on Mo2CTx-MXene@Fuc nanohybrids have identified their photothermal conversion capacity and photostability, which are crucial for photothermal therapy applications. After calibration of laser devices at 808 and 1064 nm, the nanohybrids' response to laser exposure was monitored, with temperature changes recorded via a thermal camera. Additionally, the photothermal conversion capacity was deduced from heating and cooling durations, while singlet oxygen production efficiency was evaluated using the 1,3-Diphenylisobenzofuran (DPBF) fluorescent probe. These findings underscore the potential of Mo2CTx-MXene@Fuc nanomaterials in photothermal therapy, particularly their efficiency in converting NIR radiation into therapeutic heat.
