Photothermal and photodynamic responses of core-shell Mo2C@C@Fucoidan nanospheres

[ X ]

Tarih

2025

Dergi Başlığı

Dergi ISSN

Cilt Başlığı

Yayıncı

Elsevier Science Sa

Erişim Hakkı

info:eu-repo/semantics/closedAccess

Özet

Mo2C structure, a transition metal carbide, is known for its exceptional properties including high chemical and thermal stability and surface activity. Recently, carbon-modified Mo2C structures have found widespread applications due to their effectiveness. Here, we synthesized pomegranate-like Mo2C@C nanospheres and coated them with poly(allylamine hydrochloride) (PAH) and fucoidan structures. Characterization techniques including FE-SEM, HR-TEM, XRD, XPS, and zeta potential analysis were employed. We investigated the effect of Mo2C@C@Fuc nanospheres by quantitatively evaluating their photothermal conversion efficiency. Under irradiation at wavelengths of 808 nm and 1064 nm with a power intensity of 2 W/cm2, these nanospheres could convert up to 15 % of the incident laser energy into heat, outperforming conventional materials. Stability tests in various physiological pH environments confirmed their durability under NIR irradiation, ensuring operational integrity in biological environments. In addition, they showed significant efficiency in the production of singlet oxygen, making them promising agents for PDT. Biodegradation studies indicated safe degradation after ther- apeutic application, highlighting their environmental and physiological compatibility. Integrating Mo2C@C@- Fuc nanospheres into anticancer strategies combines the advantages of PTT and PDT, promising improved therapeutic outcomes with high biocompatibility.

Açıklama

Anahtar Kelimeler

Mo2C@C nanosphere, Fucoidan, Mo2C@C@Fuc, Photothermal conversation efficiency, ROS generation

Kaynak

Materials Chemistry and Physics

WoS Q Değeri

Q2

Scopus Q Değeri

Q1

Cilt

329

Sayı

Künye