A Cr2AlC MAX Phase-Based Electrochemical Probe for the Detection of Asciminib in Biological and Pharmaceutical Samples
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Tarih
2025
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Wiley-V C H Verlag Gmbh
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
The Cr2AlC MAX phase, a two-dimensional transition metal carbide, offers a compelling combination of properties ideal for electrochemical sensor fabrication. The exceptional electrical conductivity, high surface area, and inherent electrocatalytic activity of the catalyst enable the sensitive and selective detection of diverse analytes, including biomolecules of critical clinical relevance. This work presents the construction of a novel electrochemical sensor featuring a nanoscale Cr2AlC MAX phase-modified electrode, demonstrating its exceptional analytical performance in Asciminib detection, a crucial aspect of chronic myeloid leukemia (CML) treatment. The sensor exhibits a low limit of detection (0.212 mu M) and a low limit of quantification (0.698 mu M) and demonstrates excellent sensitivity toward Asciminib in the linear range of 1 mu M-10 mu M. Moreover, a rigorous tolerance limit has been established, allowing the sensor to tolerate the highest concentration of interfering substances with an error of less than +/- 5% in determining ASC current. Successful quantification of Asciminibin biological samples further validates the method's reliability for real-world applications. This novel electrochemical approach provides a rapid and cost-effective alternative to existing methods and contributes significantly to the nanomaterial-enabled advancement of CML management, ensuring precise Asciminib quantification at the nanoscale.
Açıklama
Anahtar Kelimeler
Anticancer drug, Asciminib, Cr2AlC MAX phase, Electrochemical sensor, Pharmaceutical analysis
Kaynak
Chemistryselect
WoS Q Değeri
Q3
Scopus Q Değeri
Q3
Cilt
10
Sayı
2
