Development of a Cr2AlC MAX phase/g-C3N4 composite-based electrochemical sensor for accurate cabotegravir determination in pharmaceutical and biological samples

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dc.authoridhttps://orcid.org/0000-0003-2807-0425
dc.authorscopusid58653955500
dc.authorscopusid57224482924
dc.authorscopusid36088420200
dc.authorwosidAAM-8078-2020
dc.contributor.authorBouali, Wiem
dc.contributor.authorGenc, Asena Ayse
dc.contributor.authorErk, Nevin
dc.contributor.authorKaya, Gul
dc.contributor.authorSert, Buse
dc.contributor.authorOcakoğlu, Kasım
dc.date.accessioned2024-05-07T12:58:59Z
dc.date.available2024-05-07T12:58:59Z
dc.date.issued2024
dc.departmentFakülteler, Mühendislik Fakültesi, Mühendislik Temel Bilimleri Bölümü
dc.description.abstractA highly sensitive electrochemical sensor is reported that employs a modified electrode for the precise measurement of cabotegravir, a potent anti-HIV drug. Cyclic voltammetry (CV), differential pulse voltammetry (DPV), and electrochemical impedance spectroscopy (EIS) were utilized for this purpose. Electrode modification involved the immobilization of Cr2AlC MAX phase/g-C3N4 onto a glassy carbon electrode (GCE) to enhance its electrocatalytic activity and selectivity for cabotegravir detection. Under the optimal experimental conditions, the working potential (vs. Ag/AgCl) was to 0.93 V. The developed sensor exhibited a good linear relationship in the range 0.05 µM to 9.34 µM with a low limit of detection of 4.33 nM, signifying its exceptional sensitivity. Additionally, it demonstrated successful cabotegravir detection in pharmaceutical formulations and biological samples, achieving an RSD below 3.0%. The recoveries fell within the range 97.7 to 102%, confirming the sensor's potential for real-sample applications. This innovative electrochemical sensor represents a significant advancement, providing a simple, reliable, and sensitive tool for the accurate measurement of cabotegravir. Its potential applications include optimizing drug dosages, monitoring treatment responses, and supporting the development of cabotegravir-based pharmaceutical products, thereby contributing to advancements in HIV therapy and prevention strategies.
dc.identifier.citationBouali, W., Genc, A.A., Erk, N., Kaya, G., Sert, B ve Ocakoğlu, K.(2024). Development of a Cr2AlC MAX phase/g-C3N4 composite-based electrochemical sensor for accurate cabotegravir determination in pharmaceutical and biological samples. Microchim Acta 191, 135. https://doi.org/10.1007/s00604-024-06207-5
dc.identifier.doi10.1007/s00604-024-06207-5
dc.identifier.issue3en_US
dc.identifier.pmid38355771
dc.identifier.scopus2-s2.0-85185108194
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85185108194&doi=10.1007%2fs00604-024-06207-5&partnerID=40&md5=b2876a58ef2f8a6742bb76166d8a8f2d
dc.identifier.urihttps://hdl.handle.net/20.500.13099/226
dc.identifier.volume191en_US
dc.identifier.wosWOS:001161852300001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorKaya, Gül
dc.institutionauthorSert, Buse
dc.institutionauthorOcakoğlu, Kasım
dc.language.isoen
dc.publisherSpringer
dc.relation.ispartofMicrochimica Acta
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectCabotegravir
dc.subjectCr2AlC MAX phase
dc.subjectDifferential pulse voltammetry
dc.subjectElectrochemical sensor
dc.subjectg-C3N4
dc.subjectModified glassy carbon electrode
dc.subjectPharmaceutical products
dc.subjectCarbon
dc.subjectDiketopiperazines
dc.subjectElectrochemical Techniques
dc.subjectLimit of Detection
dc.subjectPharmaceutical Preparations
dc.subjectPyridones
dc.subjectAluminum compounds
dc.subjectCyclic voltammetry
dc.subjectDrug dosage
dc.subjectDrug products
dc.subjectElectrochemical impedance spectroscopy
dc.subjectGlass
dc.subjectGlass membrane electrodes
dc.subjectcabotegravir
dc.subjectBiological samples
dc.subjectMAX-phase
dc.subjectModified electrodes
dc.subjectModified glassy carbon electrode
dc.subjectPharmaceutical products
dc.titleDevelopment of a Cr2AlC MAX phase/g-C3N4 composite-based electrochemical sensor for accurate cabotegravir determination in pharmaceutical and biological samples
dc.typeArticle

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