Development of a Cr2AlC MAX phase/g-C3N4 composite-based electrochemical sensor for accurate cabotegravir determination in pharmaceutical and biological samples
dc.authorid | https://orcid.org/0000-0003-2807-0425 | en_US |
dc.authorscopusid | 58653955500 | en_US |
dc.authorscopusid | 57224482924 | en_US |
dc.authorscopusid | 36088420200 | en_US |
dc.authorwosid | AAM-8078-2020 | en_US |
dc.contributor.author | Bouali, Wiem | |
dc.contributor.author | Genc, Asena Ayse | |
dc.contributor.author | Erk, Nevin | |
dc.contributor.author | Kaya, Gul | |
dc.contributor.author | Sert, Buse | |
dc.contributor.author | Ocakoğlu, Kasım | |
dc.date.accessioned | 2024-05-07T12:58:59Z | |
dc.date.available | 2024-05-07T12:58:59Z | |
dc.date.issued | 2024 | en_US |
dc.department | Fakülteler, Mühendislik Fakültesi, Mühendislik Temel Bilimleri Bölümü | en_US |
dc.description.abstract | A highly sensitive electrochemical sensor is reported that employs a modified electrode for the precise measurement of cabotegravir, a potent anti-HIV drug. Cyclic voltammetry (CV), differential pulse voltammetry (DPV), and electrochemical impedance spectroscopy (EIS) were utilized for this purpose. Electrode modification involved the immobilization of Cr2AlC MAX phase/g-C3N4 onto a glassy carbon electrode (GCE) to enhance its electrocatalytic activity and selectivity for cabotegravir detection. Under the optimal experimental conditions, the working potential (vs. Ag/AgCl) was to 0.93 V. The developed sensor exhibited a good linear relationship in the range 0.05 µM to 9.34 µM with a low limit of detection of 4.33 nM, signifying its exceptional sensitivity. Additionally, it demonstrated successful cabotegravir detection in pharmaceutical formulations and biological samples, achieving an RSD below 3.0%. The recoveries fell within the range 97.7 to 102%, confirming the sensor's potential for real-sample applications. This innovative electrochemical sensor represents a significant advancement, providing a simple, reliable, and sensitive tool for the accurate measurement of cabotegravir. Its potential applications include optimizing drug dosages, monitoring treatment responses, and supporting the development of cabotegravir-based pharmaceutical products, thereby contributing to advancements in HIV therapy and prevention strategies. | en_US |
dc.identifier.citation | Bouali, W., Genc, A.A., Erk, N., Kaya, G., Sert, B ve Ocakoğlu, K.(2024). Development of a Cr2AlC MAX phase/g-C3N4 composite-based electrochemical sensor for accurate cabotegravir determination in pharmaceutical and biological samples. Microchim Acta 191, 135. https://doi.org/10.1007/s00604-024-06207-5 | en_US |
dc.identifier.doi | 10.1007/s00604-024-06207-5 | en_US |
dc.identifier.issue | 3 | en_US |
dc.identifier.pmid | 38355771 | en_US |
dc.identifier.scopus | 2-s2.0-85185108194 | en_US |
dc.identifier.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85185108194&doi=10.1007%2fs00604-024-06207-5&partnerID=40&md5=b2876a58ef2f8a6742bb76166d8a8f2d | |
dc.identifier.uri | https://hdl.handle.net/20.500.13099/226 | |
dc.identifier.volume | 191 | en_US |
dc.identifier.wosquality | Q1 | en_US |
dc.institutionauthor | Kaya, Gül | |
dc.institutionauthor | Sert, Buse | |
dc.institutionauthor | Ocakoğlu, Kasım | |
dc.language.iso | eng | en_US |
dc.publisher | Springer | en_US |
dc.relation.ispartof | Microchimica Acta | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.rights | info:eu-repo/semantics/restrictedAccess | en_US |
dc.subject | Cabotegravir | en_US |
dc.subject | Cr2AlC MAX phase | en_US |
dc.subject | Differential pulse voltammetry | en_US |
dc.subject | Electrochemical sensor | en_US |
dc.subject | g-C3N4 | en_US |
dc.subject | Modified glassy carbon electrode | en_US |
dc.subject | Pharmaceutical products | en_US |
dc.subject | Carbon | en_US |
dc.subject | Diketopiperazines | en_US |
dc.subject | Electrochemical Techniques | en_US |
dc.subject | Limit of Detection | en_US |
dc.subject | Pharmaceutical Preparations | en_US |
dc.subject | Pyridones | en_US |
dc.subject | Aluminum compounds | en_US |
dc.subject | Cyclic voltammetry | en_US |
dc.subject | Drug dosage | en_US |
dc.subject | Drug products | en_US |
dc.subject | Electrochemical impedance spectroscopy | en_US |
dc.subject | Glass | en_US |
dc.subject | Glass membrane electrodes | en_US |
dc.subject | cabotegravir | en_US |
dc.subject | Biological samples | en_US |
dc.subject | MAX-phase | en_US |
dc.subject | Modified electrodes | en_US |
dc.subject | Modified glassy carbon electrode | en_US |
dc.subject | Pharmaceutical products | en_US |
dc.title | Development of a Cr2AlC MAX phase/g-C3N4 composite-based electrochemical sensor for accurate cabotegravir determination in pharmaceutical and biological samples | en_US |
dc.type | article | en_US |