Development of a Cr2AlC MAX phase/g-C3N4 composite-based electrochemical sensor for accurate cabotegravir determination in pharmaceutical and biological samples

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dc.authoridhttps://orcid.org/0000-0003-2807-0425en_US
dc.authorscopusid58653955500en_US
dc.authorscopusid57224482924en_US
dc.authorscopusid36088420200en_US
dc.authorwosidAAM-8078-2020en_US
dc.contributor.authorBouali, Wiem
dc.contributor.authorGenc, Asena Ayse
dc.contributor.authorErk, Nevin
dc.contributor.authorKaya, Gul
dc.contributor.authorSert, Buse
dc.contributor.authorOcakoğlu, Kasım
dc.date.accessioned2024-05-07T12:58:59Z
dc.date.available2024-05-07T12:58:59Z
dc.date.issued2024en_US
dc.departmentFakülteler, Mühendislik Fakültesi, Mühendislik Temel Bilimleri Bölümüen_US
dc.description.abstractA highly sensitive electrochemical sensor is reported that employs a modified electrode for the precise measurement of cabotegravir, a potent anti-HIV drug. Cyclic voltammetry (CV), differential pulse voltammetry (DPV), and electrochemical impedance spectroscopy (EIS) were utilized for this purpose. Electrode modification involved the immobilization of Cr2AlC MAX phase/g-C3N4 onto a glassy carbon electrode (GCE) to enhance its electrocatalytic activity and selectivity for cabotegravir detection. Under the optimal experimental conditions, the working potential (vs. Ag/AgCl) was to 0.93 V. The developed sensor exhibited a good linear relationship in the range 0.05 µM to 9.34 µM with a low limit of detection of 4.33 nM, signifying its exceptional sensitivity. Additionally, it demonstrated successful cabotegravir detection in pharmaceutical formulations and biological samples, achieving an RSD below 3.0%. The recoveries fell within the range 97.7 to 102%, confirming the sensor's potential for real-sample applications. This innovative electrochemical sensor represents a significant advancement, providing a simple, reliable, and sensitive tool for the accurate measurement of cabotegravir. Its potential applications include optimizing drug dosages, monitoring treatment responses, and supporting the development of cabotegravir-based pharmaceutical products, thereby contributing to advancements in HIV therapy and prevention strategies.en_US
dc.identifier.citationBouali, W., Genc, A.A., Erk, N., Kaya, G., Sert, B ve Ocakoğlu, K.(2024). Development of a Cr2AlC MAX phase/g-C3N4 composite-based electrochemical sensor for accurate cabotegravir determination in pharmaceutical and biological samples. Microchim Acta 191, 135. https://doi.org/10.1007/s00604-024-06207-5en_US
dc.identifier.doi10.1007/s00604-024-06207-5en_US
dc.identifier.issue3en_US
dc.identifier.pmid38355771en_US
dc.identifier.scopus2-s2.0-85185108194en_US
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85185108194&doi=10.1007%2fs00604-024-06207-5&partnerID=40&md5=b2876a58ef2f8a6742bb76166d8a8f2d
dc.identifier.urihttps://hdl.handle.net/20.500.13099/226
dc.identifier.volume191en_US
dc.identifier.wosqualityQ1en_US
dc.institutionauthorKaya, Gül
dc.institutionauthorSert, Buse
dc.institutionauthorOcakoğlu, Kasım
dc.language.isoengen_US
dc.publisherSpringeren_US
dc.relation.ispartofMicrochimica Actaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/restrictedAccessen_US
dc.subjectCabotegraviren_US
dc.subjectCr2AlC MAX phaseen_US
dc.subjectDifferential pulse voltammetryen_US
dc.subjectElectrochemical sensoren_US
dc.subjectg-C3N4en_US
dc.subjectModified glassy carbon electrodeen_US
dc.subjectPharmaceutical productsen_US
dc.subjectCarbonen_US
dc.subjectDiketopiperazinesen_US
dc.subjectElectrochemical Techniquesen_US
dc.subjectLimit of Detectionen_US
dc.subjectPharmaceutical Preparationsen_US
dc.subjectPyridonesen_US
dc.subjectAluminum compoundsen_US
dc.subjectCyclic voltammetryen_US
dc.subjectDrug dosageen_US
dc.subjectDrug productsen_US
dc.subjectElectrochemical impedance spectroscopyen_US
dc.subjectGlassen_US
dc.subjectGlass membrane electrodesen_US
dc.subjectcabotegraviren_US
dc.subjectBiological samplesen_US
dc.subjectMAX-phaseen_US
dc.subjectModified electrodesen_US
dc.subjectModified glassy carbon electrodeen_US
dc.subjectPharmaceutical productsen_US
dc.titleDevelopment of a Cr2AlC MAX phase/g-C3N4 composite-based electrochemical sensor for accurate cabotegravir determination in pharmaceutical and biological samplesen_US
dc.typearticleen_US

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