Innovative approach against cancer: Thymoquinone-loaded PHEMA-based magnetic nanoparticles and their effects on MCF-7 breast cancer

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dc.authoridhttps://orcid.org/0000-0002-2511-6478
dc.authorscopusid57193389683
dc.authorscopusid57192437818
dc.authorscopusid57972895000
dc.authorscopusid6504386555
dc.authorscopusid6701832216
dc.authorwosidKXV-5747-2024
dc.authorwosidKXV-5747-2024
dc.authorwosidLCM-5201-2024
dc.contributor.authorYıldırım, Metin
dc.contributor.authorAcet, Ömür
dc.contributor.authorÖnal Acet, Burcu
dc.contributor.authorKarakoç, Veyis
dc.contributor.authorOdabaşı, Mehmet
dc.date.accessioned2024-08-26T13:06:04Z
dc.date.available2024-08-26T13:06:04Z
dc.date.issued2024
dc.departmentMeslek Yüksekokulları, Sağlık Hizmetleri Meslek Yüksekokulu, Eczane Hizmetleri Bölümü
dc.description.abstractBreast cancer is most common cancer among women in the World. Thymoquinone (TQ) exhibits a wide range of biological activities such as anticancer, antidiabetic, antimicrobial, analgesic, antioxidant, and anti-inflammatory effects. However, its effectiveness in cancer treatment is hindered by its poor bioavailability, attributed to its limited solubility in water. Hence, novel strategies are required to enhance the bioavailability of TQ, which possesses remarkable anticancer characteristics. The aim of this study is to prepare pHEMA-based magnetic nanoparticles carrying TQ (TQ-MNPs) to improve bioavailability, and therapeutic efficacy against breast cancer. For this purpose, TQ-MNPs were synthesized and characterized with Fourier transform infrared spectrophotometer (FTIR), scanning electron microscopy (SEM), dynamic light scattering (DLS), magnetic field using a vibrating sample magnetometer (VSM). The loading capabilities of synthesized magentic nanostructures were evaluated, and release investigations were conducted under experimental conditions that mimic the cellular environment. The findings of the studies indicated that the TQ carrying capacity of MNPs was deemed satisfactory, and the release efficiency was adequate. MNPs and TQ-MNPs showed biocompatibility against HDFa cells. TQ-MNPs showed stronger anti-proliferative activity against MCF-7 breast cancer cells compared to free TQ (p < 0.05). TQ-MNPs induced apoptosis in MCF-7 breast cancer cells.
dc.identifier.citationYıldırım, M., Acet, Ö., Önal Acet, B., Karakoç, V., Odabaşı,M. (2024). Innovative approach against cancer: Thymoquinone-loaded PHEMA-based magnetic nanoparticles and their effects on MCF-7 breast cancer, Biochemical and Biophysical Research Communications,734. Erişim adresi: https://doi.org/10.1016/j.bbrc.2024.150464.
dc.identifier.doi10.1016/j.bbrc.2024.150464
dc.identifier.endpage7en_US
dc.identifier.pmid39083970
dc.identifier.scopus2-s2.0-85199687072
dc.identifier.scopusqualityQ2
dc.identifier.startpage1en_US
dc.identifier.urihttps://doi.org/10.1016/j.bbrc.2024.150464
dc.identifier.urihttps://hdl.handle.net/20.500.13099/367
dc.identifier.volume734en_US
dc.identifier.wosWOS:001284823600001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorAcet, Ömür
dc.language.isoen
dc.publisherElsevier
dc.relation.ispartofBiochemical and Biophysical Research Communications
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectCancer
dc.subjectMagnetic nanoparticles
dc.subjectMCF-7
dc.subjectThymoquinone
dc.titleInnovative approach against cancer: Thymoquinone-loaded PHEMA-based magnetic nanoparticles and their effects on MCF-7 breast cancer
dc.typeArticle

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