Innovative approach against cancer: Thymoquinone-loaded PHEMA-based magnetic nanoparticles and their effects on MCF-7 breast cancer

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dc.authoridhttps://orcid.org/0000-0002-2511-6478en_US
dc.authorscopusid57193389683en_US
dc.authorscopusid57192437818en_US
dc.authorscopusid57972895000en_US
dc.authorscopusid6504386555en_US
dc.authorscopusid6701832216en_US
dc.authorwosidKXV-5747-2024en_US
dc.authorwosidKXV-5747-2024en_US
dc.authorwosidLCM-5201-2024en_US
dc.contributor.authorYıldırım, Metin
dc.contributor.authorAcet, Ömür
dc.contributor.authorÖnal Acet, Burcu
dc.contributor.authorKarakoç, Veyis
dc.contributor.authorOdabaşı, Mehmet
dc.date.accessioned2024-08-26T13:06:04Z
dc.date.available2024-08-26T13:06:04Z
dc.date.issued2024en_US
dc.departmentMeslek Yüksekokulları, Sağlık Hizmetleri Meslek Yüksekokulu, Eczane Hizmetleri Bölümüen_US
dc.description.abstractBreast cancer is most common cancer among women in the World. Thymoquinone (TQ) exhibits a wide range of biological activities such as anticancer, antidiabetic, antimicrobial, analgesic, antioxidant, and anti-inflammatory effects. However, its effectiveness in cancer treatment is hindered by its poor bioavailability, attributed to its limited solubility in water. Hence, novel strategies are required to enhance the bioavailability of TQ, which possesses remarkable anticancer characteristics. The aim of this study is to prepare pHEMA-based magnetic nanoparticles carrying TQ (TQ-MNPs) to improve bioavailability, and therapeutic efficacy against breast cancer. For this purpose, TQ-MNPs were synthesized and characterized with Fourier transform infrared spectrophotometer (FTIR), scanning electron microscopy (SEM), dynamic light scattering (DLS), magnetic field using a vibrating sample magnetometer (VSM). The loading capabilities of synthesized magentic nanostructures were evaluated, and release investigations were conducted under experimental conditions that mimic the cellular environment. The findings of the studies indicated that the TQ carrying capacity of MNPs was deemed satisfactory, and the release efficiency was adequate. MNPs and TQ-MNPs showed biocompatibility against HDFa cells. TQ-MNPs showed stronger anti-proliferative activity against MCF-7 breast cancer cells compared to free TQ (p < 0.05). TQ-MNPs induced apoptosis in MCF-7 breast cancer cells.en_US
dc.identifier.citationYıldırım, M., Acet, Ö., Önal Acet, B., Karakoç, V., Odabaşı,M. (2024). Innovative approach against cancer: Thymoquinone-loaded PHEMA-based magnetic nanoparticles and their effects on MCF-7 breast cancer, Biochemical and Biophysical Research Communications,734. Erişim adresi: https://doi.org/10.1016/j.bbrc.2024.150464.en_US
dc.identifier.doi10.1016/j.bbrc.2024.150464en_US
dc.identifier.endpage7en_US
dc.identifier.pmid39083970en_US
dc.identifier.scopus2-s2.0-85199687072en_US
dc.identifier.startpage1en_US
dc.identifier.urihttps://doi.org/10.1016/j.bbrc.2024.150464
dc.identifier.urihttps://hdl.handle.net/20.500.13099/367
dc.identifier.volume734en_US
dc.identifier.wos001284823600001en_US
dc.identifier.wosqualityQ3en_US
dc.institutionauthorAcet, Ömür
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.relation.ispartofBiochemical and Biophysical Research Communicationsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCanceren_US
dc.subjectMagnetic nanoparticlesen_US
dc.subjectMCF-7en_US
dc.subjectThymoquinoneen_US
dc.titleInnovative approach against cancer: Thymoquinone-loaded PHEMA-based magnetic nanoparticles and their effects on MCF-7 breast canceren_US
dc.typearticleen_US

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