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Öğe Innovative approach against cancer: Thymoquinone-loaded PHEMA-based magnetic nanoparticles and their effects on MCF-7 breast cancer(Elsevier, 2024) Yıldırım, Metin; Acet, Ömür; Önal Acet, Burcu; Karakoç, Veyis; Odabaşı, MehmetBreast cancer is most common cancer among women in the World. Thymoquinone (TQ) exhibits a wide range of biological activities such as anticancer, antidiabetic, antimicrobial, analgesic, antioxidant, and anti-inflammatory effects. However, its effectiveness in cancer treatment is hindered by its poor bioavailability, attributed to its limited solubility in water. Hence, novel strategies are required to enhance the bioavailability of TQ, which possesses remarkable anticancer characteristics. The aim of this study is to prepare pHEMA-based magnetic nanoparticles carrying TQ (TQ-MNPs) to improve bioavailability, and therapeutic efficacy against breast cancer. For this purpose, TQ-MNPs were synthesized and characterized with Fourier transform infrared spectrophotometer (FTIR), scanning electron microscopy (SEM), dynamic light scattering (DLS), magnetic field using a vibrating sample magnetometer (VSM). The loading capabilities of synthesized magentic nanostructures were evaluated, and release investigations were conducted under experimental conditions that mimic the cellular environment. The findings of the studies indicated that the TQ carrying capacity of MNPs was deemed satisfactory, and the release efficiency was adequate. MNPs and TQ-MNPs showed biocompatibility against HDFa cells. TQ-MNPs showed stronger anti-proliferative activity against MCF-7 breast cancer cells compared to free TQ (p < 0.05). TQ-MNPs induced apoptosis in MCF-7 breast cancer cells.Öğe Perceptions of Children and Childhood in the Context of New Childhood Sociology(Springer, 2021) Şerife, Hülya KurtFor many years, people throughout the world have strived to eliminate "weakness" in children so that they can become healthy adults. The label of "adult of the future" often shapes many children's social identity and obscures the importance of their lives as children. Due to these criticisms, new childhood sociology aims at explaining childhood in contexts which emphasize that children should be determinants of their own lives. It is stated that children should be treated as independent and separate from the adult perspective. In this context, the aim of this study was to examine children and childhood in the context of new childhood sociology based on the perceptions of students of child development. As a result, it was observed that the participants' perceptions of children and childhood concentrated around the expressions of being "inadequate, incomplete, pure, adult dependent, and mediation of becoming an adult". Additionally, a discussion was provided regarding the study results and recommendations in the context of new childhood sociology.
