Electrospun nanofiber mats caged the mammalian macrophages on their surfaces and prevented their inflammatory responses independent of the fiber diameter

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dc.authoridhttps://orcid.org/0000-0002-2977-2077 View this author’s ORCID profile
dc.authorscopusid55820407700
dc.authorwosidH-6376-2017
dc.contributor.authorAyaz, Furkan
dc.contributor.authorDemir, Didem
dc.contributor.authorBölgen, Nimet
dc.date.accessioned2024-08-26T11:57:49Z
dc.date.available2024-08-26T11:57:49Z
dc.date.issued2024
dc.departmentMeslek Yüksekokulları, Mersin Tarsus OSB Teknik Bilimler Meslek Yüksekokulu, Kimya ve Kimyasal İşleme Teknolojileri Bölümü
dc.description.abstractPoly-?-caprolactone (PCL) has been widely used as biocompatible materials in tissue engineering. They have been used in mammalian cell proliferation to polarization and differentiation. Their modified versions had regulatory activities on mammalian macrophages in vitro. There are also studies suggesting different nanofiber diameters might alter the biological activities of these materials. Based on these cues, we examined the inflammatory activities and adherence properties of mammalian macrophages on electrospun PCL nanofibrous scaffolds formed with PCL having different nanofiber diameters. Our results suggest that macrophages could easily attach and get dispersed on the scaffolds. Macrophages lost their inflammatory cytokine TNF and IL6 production capacity in the presence of LPS when they were incubated on nanofibers. These effects were independent of the mean fiber diameters. Overall, the scaffolds have potential to be used as biocompatible materials to suppress excessive inflammatory reactions during tissue and organ transplantation by caging and suppressing the inflammatory cells.
dc.identifier.citationAyaz, F., Demir, D. ve Bölgen, N. (2024). Electrospun nanofiber mats caged the mammalian macrophages on their surfaces and prevented their inflammatory responses independent of the fiber diameter. Scientific Reports, 14 (1), 12339. https://doi.org/10.1038/s41598-024-61450-3
dc.identifier.doi10.1038/s41598-024-61450-3
dc.identifier.endpage8en_US
dc.identifier.issn2045-2322
dc.identifier.issue1en_US
dc.identifier.pmid38811651
dc.identifier.scopus2-s2.0-85194712804
dc.identifier.scopusqualityQ1
dc.identifier.startpage1en_US
dc.identifier.urihttps://doi.org/10.1038/s41598-024-61450-3
dc.identifier.urihttps://hdl.handle.net/20.500.13099/364
dc.identifier.volume14en_US
dc.identifier.wosWOS:001235693100055
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorDemir, Didem
dc.language.isoen
dc.publisherNature Portfolio
dc.relation.ispartofScientific Reports
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectElectrospinning
dc.subjectImmunotoxicity
dc.subjectInflammation
dc.subjectMacrophages
dc.subjectPCL
dc.titleElectrospun nanofiber mats caged the mammalian macrophages on their surfaces and prevented their inflammatory responses independent of the fiber diameter
dc.typeArticle

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