Electrospun nanofiber mats caged the mammalian macrophages on their surfaces and prevented their inflammatory responses independent of the fiber diameter

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dc.authoridhttps://orcid.org/0000-0002-2977-2077 View this author’s ORCID profileen_US
dc.authorscopusid55820407700en_US
dc.authorwosidH-6376-2017en_US
dc.contributor.authorAyaz, Furkan
dc.contributor.authorDemir, Didem
dc.contributor.authorBölgen, Nimet
dc.date.accessioned2024-08-26T11:57:49Z
dc.date.available2024-08-26T11:57:49Z
dc.date.issued2024en_US
dc.departmentMeslek Yüksekokulları, Mersin Tarsus OSB Teknik Bilimler Meslek Yüksekokulu, Kimya ve Kimyasal İşleme Teknolojileri Bölümüen_US
dc.description.abstractPoly-ε-caprolactone (PCL) has been widely used as biocompatible materials in tissue engineering. They have been used in mammalian cell proliferation to polarization and differentiation. Their modified versions had regulatory activities on mammalian macrophages in vitro. There are also studies suggesting different nanofiber diameters might alter the biological activities of these materials. Based on these cues, we examined the inflammatory activities and adherence properties of mammalian macrophages on electrospun PCL nanofibrous scaffolds formed with PCL having different nanofiber diameters. Our results suggest that macrophages could easily attach and get dispersed on the scaffolds. Macrophages lost their inflammatory cytokine TNF and IL6 production capacity in the presence of LPS when they were incubated on nanofibers. These effects were independent of the mean fiber diameters. Overall, the scaffolds have potential to be used as biocompatible materials to suppress excessive inflammatory reactions during tissue and organ transplantation by caging and suppressing the inflammatory cells.en_US
dc.identifier.citationAyaz, F., Demir, D. ve Bölgen, N. (2024). Electrospun nanofiber mats caged the mammalian macrophages on their surfaces and prevented their inflammatory responses independent of the fiber diameter. Scientific Reports, 14 (1), 12339. https://doi.org/10.1038/s41598-024-61450-3en_US
dc.identifier.doi10.1038/s41598-024-61450-3en_US
dc.identifier.endpage8en_US
dc.identifier.issn2045-2322
dc.identifier.issue1en_US
dc.identifier.pmid38811651en_US
dc.identifier.scopus2-s2.0-85194712804en_US
dc.identifier.startpage1en_US
dc.identifier.urihttps://doi.org/10.1038/s41598-024-61450-3
dc.identifier.urihttps://hdl.handle.net/20.500.13099/364
dc.identifier.volume14en_US
dc.identifier.wos001235693100055en_US
dc.identifier.wosqualityQ1en_US
dc.institutionauthorDemir, Didem
dc.language.isoengen_US
dc.publisherNature Portfolioen_US
dc.relation.ispartofScientific Reportsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectElectrospinningen_US
dc.subjectImmunotoxicityen_US
dc.subjectInflammationen_US
dc.subjectMacrophagesen_US
dc.subjectPCLen_US
dc.titleElectrospun nanofiber mats caged the mammalian macrophages on their surfaces and prevented their inflammatory responses independent of the fiber diameteren_US
dc.typearticleen_US

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