Yazar "Yildirim, M." seçeneğine göre listele

Listeleniyor 1 - 4 / 4
  • [ X ]
    Öğe
    Anti-Inflammatory Effects of Coumarin-Selenophene Derivatives on LPS-Stimulated RAW 264.7 Macrophage Cells
    (Maik Nauka/Interperiodica/Springer, 2022) Yildirim, M.; Unal, Z. N.; Ersatir, M.; Yetkin, D.; Degirmenci, U.; Giray, E. S.
    Coumarin and coumarin derivatives have been known for their anti-viral, anti-oxidant, anti-cancer and anti-inflammatory activities. Changes in biological activity when these biologically active compounds are combined with different heterocyclic groups are among the topics of interest to researchers in recent years. Therefore, a series of coumarin-selenophene hybrid compounds have been synthesized. Products are fully characterized by NMR and FT-IR spectroscopic techniques. The prepared compounds are screened for their anti-inflammatory potencies on LPS induced mouse macrophage cell line (RAW 264.7). The results showed that coumarin-selenophene hybrid compounds were not cytotoxic at the tested concentrations on RAW 264.7 macrophages. Also, these compounds decreased TNF- alpha, IL-6 secretion, and NO, PGE(2) production in dose-depended manner. According to our results, coumarin-selenophene hybrid compounds have the capacity to moderate the immune response and a potential anti-inflammatory activity.
  • [ X ]
    Öğe
    Coumarin Hybrids as Cholinesterase Inhibitors
    (Maik Nauka/Interperiodica/Springer, 2023) Yildirim, M.; Ersatir, M.; Yalin, S.; Giray, E. S.
    Acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) are two important enzymes involved in the breakdown of the neurotransmitter acetylcholine and other choline esters. Coumarins are biologically active compounds naturally found in the fruit, bark, stems, and leaves of many plants, including Tonka bean, acacia, lavender, deer tongue, apricot, strawberry, cherry, and cinnamon. Coumarin and coumarin hybrids have antitumor, antioxidant, antiviral, anticonvulsant, anti-inflammatory, antimicrobial, and antiproliferative activity. AChE and BuChE enzyme inhibition effects of 12 different coumarin derivatives (Ia-Ih) and (IIa-IId) synthesized and 16 coumarin-selenophene hybrid compounds (IVa-IVh) and (Va-Vh) were investigated. Compound (Vc) and (Vg) showed the most potent inhibitor activity against AChE.
  • [ X ]
    Öğe
    PUNICALAGIN AND PUNICALIN SUPPRESS THE ADIPOCYTE DIFFERENTIATION THROUGH THE TRANSCRIPTION FACTORS
    (Editura Acad Romane, 2021) Berkoz, M.; Yalin, S.; Yildirim, M.; Yalin, A. E.; Comelekoglu, U.
    Background. Pomegranate is a rich source of many polyphenolic compounds including ellagitannins (punicalagin, punicalin and others). Aim. The effects of punicalagin and punicalin on adipogenesis were investigated in this study. Materials and Methods. To examine the effect of punicalagin and punicalin on adipocyte differentiation, various concentrations of punicalagin and punicalin (2-10 mu M) were applied to differentiated 3T3-L1 cells. Glyceraldehyde-3-phosphate dehydrogenase (GPDH) activity, Oil red O staining, intracellular triglyceride levels, and gene expressions of transcription factors (Peroxisome proliferator-activated receptor-gamma (PPAR gamma), CCAAT-enhancer-binding proteins-alpha (C/EBP alpha), Sterol regulatory element-binding protein 1c (SREBP-1c)) and lipolysisassociated genes (hormone-sensitive lipase (HSL), Perilipin A, tumor necrosis factor-alpha (TNF-alpha)) were examined in order to investigate the effects of punicalagin and punicalin on adipocyte differentiation. Results. Punicalagin and punicalin applications caused a continuous decrease in cell size and intracellular triglyceride accumulation. GPDH activity and transcription gene expressions decreased significantly in groups that were applicated punicalagin and punicalin at high concentrations. Punicalagin, but not punicalin, down-regulated the expression of HSL and perilipin A and up-regulated the expression of TNF-alpha in a dose-dependent manner. In conclusion, both punicalagin and punicalin were able to inhibit the adipocyte differentiation.
  • [ X ]
    Öğe
    The Effect of Sitagliptin and Exenatide on Insulin, Insulin Receptor and Insulin Receptor Substrate Gene Expression in Diabetic Rats
    (Maik Nauka/Interperiodica/Springer, 2023) Yildirim, M.; Mistik, O. Agtas; Yalin, A. E.; Comelekoglu, U.; Berkoz, M.; Arpaci, R. Bozdogan; Yalin, S.
    Diabetes mellitus is a chronic metabolic disorder characterized by persistent hyperglycemia that results from abnormal secretion of insulin, inappropriate action of insulin or both. The aim of this study is to determine the effects of exenatide and sitagliptin treatment on the expression of insulin (INS-1), insulin receptor (INSR) and insulin receptor substrate (IRS-1) genes. In this study streptozotocin-induced diabetic rats were treated with sitagliptin (10 mg/kg) and exenatide (0.1 mu g/kg) for 15 days. We measured INS-1, INSR and IRS-1 gene expression levels and examined the histology of pancreatic tissues in all groups. Exenatide and sitagliptin treatment increased gene expression levels of INS-1, INSR and IRS-1.