Coumarin Hybrids as Cholinesterase Inhibitors
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Tarih
2023
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Maik Nauka/Interperiodica/Springer
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) are two important enzymes involved in the breakdown of the neurotransmitter acetylcholine and other choline esters. Coumarins are biologically active compounds naturally found in the fruit, bark, stems, and leaves of many plants, including Tonka bean, acacia, lavender, deer tongue, apricot, strawberry, cherry, and cinnamon. Coumarin and coumarin hybrids have antitumor, antioxidant, antiviral, anticonvulsant, anti-inflammatory, antimicrobial, and antiproliferative activity. AChE and BuChE enzyme inhibition effects of 12 different coumarin derivatives (Ia-Ih) and (IIa-IId) synthesized and 16 coumarin-selenophene hybrid compounds (IVa-IVh) and (Va-Vh) were investigated. Compound (Vc) and (Vg) showed the most potent inhibitor activity against AChE.
Açıklama
Anahtar Kelimeler
AChE, BuChE, coumarin, coumarin-selenophene, alzheimer's disease
Kaynak
Russian Journal of Bioorganic Chemistry
WoS Q Değeri
Q4
Scopus Q Değeri
Q4
Cilt
49
Sayı
5
