The Effect of Sitagliptin and Exenatide on Insulin, Insulin Receptor and Insulin Receptor Substrate Gene Expression in Diabetic Rats
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Tarih
2023
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Maik Nauka/Interperiodica/Springer
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Diabetes mellitus is a chronic metabolic disorder characterized by persistent hyperglycemia that results from abnormal secretion of insulin, inappropriate action of insulin or both. The aim of this study is to determine the effects of exenatide and sitagliptin treatment on the expression of insulin (INS-1), insulin receptor (INSR) and insulin receptor substrate (IRS-1) genes. In this study streptozotocin-induced diabetic rats were treated with sitagliptin (10 mg/kg) and exenatide (0.1 mu g/kg) for 15 days. We measured INS-1, INSR and IRS-1 gene expression levels and examined the histology of pancreatic tissues in all groups. Exenatide and sitagliptin treatment increased gene expression levels of INS-1, INSR and IRS-1.
Açıklama
Anahtar Kelimeler
exenatide, sitagliptin, diabetes, insulin, gene expression
Kaynak
Russian Journal of Bioorganic Chemistry
WoS Q Değeri
Q4
Scopus Q Değeri
Q4
Cilt
49
Sayı
3
