Yazar "Genc, Asena Ayse" seçeneğine göre listele

Listeleniyor 1 - 2 / 2
  • [ X ]
    Öğe
    A Cr2AlC MAX Phase-Based Electrochemical Probe for the Detection of Asciminib in Biological and Pharmaceutical Samples
    (Wiley-V C H Verlag Gmbh, 2025) Genc, Asena Ayse; Bouali, Wiem; Erk, Nevin; Kaya, Gul; Ocakoglu, Kasim
    The Cr2AlC MAX phase, a two-dimensional transition metal carbide, offers a compelling combination of properties ideal for electrochemical sensor fabrication. The exceptional electrical conductivity, high surface area, and inherent electrocatalytic activity of the catalyst enable the sensitive and selective detection of diverse analytes, including biomolecules of critical clinical relevance. This work presents the construction of a novel electrochemical sensor featuring a nanoscale Cr2AlC MAX phase-modified electrode, demonstrating its exceptional analytical performance in Asciminib detection, a crucial aspect of chronic myeloid leukemia (CML) treatment. The sensor exhibits a low limit of detection (0.212 mu M) and a low limit of quantification (0.698 mu M) and demonstrates excellent sensitivity toward Asciminib in the linear range of 1 mu M-10 mu M. Moreover, a rigorous tolerance limit has been established, allowing the sensor to tolerate the highest concentration of interfering substances with an error of less than +/- 5% in determining ASC current. Successful quantification of Asciminibin biological samples further validates the method's reliability for real-world applications. This novel electrochemical approach provides a rapid and cost-effective alternative to existing methods and contributes significantly to the nanomaterial-enabled advancement of CML management, ensuring precise Asciminib quantification at the nanoscale.
  • Küçük Resim
    Öğe
    Development of a Cr2AlC MAX phase/g-C3N4 composite-based electrochemical sensor for accurate cabotegravir determination in pharmaceutical and biological samples
    (Springer, 2024) Bouali, Wiem; Genc, Asena Ayse; Erk, Nevin; Kaya, Gul; Sert, Buse; Ocakoğlu, Kasım
    A highly sensitive electrochemical sensor is reported that employs a modified electrode for the precise measurement of cabotegravir, a potent anti-HIV drug. Cyclic voltammetry (CV), differential pulse voltammetry (DPV), and electrochemical impedance spectroscopy (EIS) were utilized for this purpose. Electrode modification involved the immobilization of Cr2AlC MAX phase/g-C3N4 onto a glassy carbon electrode (GCE) to enhance its electrocatalytic activity and selectivity for cabotegravir detection. Under the optimal experimental conditions, the working potential (vs. Ag/AgCl) was to 0.93 V. The developed sensor exhibited a good linear relationship in the range 0.05 µM to 9.34 µM with a low limit of detection of 4.33 nM, signifying its exceptional sensitivity. Additionally, it demonstrated successful cabotegravir detection in pharmaceutical formulations and biological samples, achieving an RSD below 3.0%. The recoveries fell within the range 97.7 to 102%, confirming the sensor's potential for real-sample applications. This innovative electrochemical sensor represents a significant advancement, providing a simple, reliable, and sensitive tool for the accurate measurement of cabotegravir. Its potential applications include optimizing drug dosages, monitoring treatment responses, and supporting the development of cabotegravir-based pharmaceutical products, thereby contributing to advancements in HIV therapy and prevention strategies.