PUNICALAGIN AND PUNICALIN SUPPRESS THE ADIPOCYTE DIFFERENTIATION THROUGH THE TRANSCRIPTION FACTORS

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dc.authoridComelekoglu, Ulku/0000-0001-8060-6333
dc.contributor.authorBerkoz, M.
dc.contributor.authorYalin, S.
dc.contributor.authorYildirim, M.
dc.contributor.authorYalin, A. E.
dc.contributor.authorComelekoglu, U.
dc.date.accessioned2025-03-17T12:25:11Z
dc.date.available2025-03-17T12:25:11Z
dc.date.issued2021
dc.departmentTarsus Üniversitesi
dc.description.abstractBackground. Pomegranate is a rich source of many polyphenolic compounds including ellagitannins (punicalagin, punicalin and others). Aim. The effects of punicalagin and punicalin on adipogenesis were investigated in this study. Materials and Methods. To examine the effect of punicalagin and punicalin on adipocyte differentiation, various concentrations of punicalagin and punicalin (2-10 mu M) were applied to differentiated 3T3-L1 cells. Glyceraldehyde-3-phosphate dehydrogenase (GPDH) activity, Oil red O staining, intracellular triglyceride levels, and gene expressions of transcription factors (Peroxisome proliferator-activated receptor-gamma (PPAR gamma), CCAAT-enhancer-binding proteins-alpha (C/EBP alpha), Sterol regulatory element-binding protein 1c (SREBP-1c)) and lipolysisassociated genes (hormone-sensitive lipase (HSL), Perilipin A, tumor necrosis factor-alpha (TNF-alpha)) were examined in order to investigate the effects of punicalagin and punicalin on adipocyte differentiation. Results. Punicalagin and punicalin applications caused a continuous decrease in cell size and intracellular triglyceride accumulation. GPDH activity and transcription gene expressions decreased significantly in groups that were applicated punicalagin and punicalin at high concentrations. Punicalagin, but not punicalin, down-regulated the expression of HSL and perilipin A and up-regulated the expression of TNF-alpha in a dose-dependent manner. In conclusion, both punicalagin and punicalin were able to inhibit the adipocyte differentiation.
dc.description.sponsorshipOffice of Scientific Research Projects of Mersin University [2016-2-TP3-1891]
dc.description.sponsorshipThis research was financially supported in part by the Office of Scientific Research Projects of Mersin University under Grant number (2016-2-TP3-1891).
dc.identifier.doi10.4183/aeb.2021.157
dc.identifier.endpage167
dc.identifier.issn1841-0987
dc.identifier.issn1843-066X
dc.identifier.issue2
dc.identifier.pmid34925563
dc.identifier.scopus2-s2.0-85125816300
dc.identifier.scopusqualityQ4
dc.identifier.startpage157
dc.identifier.urihttps://doi.org/10.4183/aeb.2021.157
dc.identifier.urihttps://hdl.handle.net/20.500.13099/1532
dc.identifier.volume17
dc.identifier.wosWOS:000746547000002
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherEditura Acad Romane
dc.relation.ispartofActa Endocrinologica-Bucharest
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20250316
dc.subject3T3-L1
dc.subjectadipogenesis
dc.subjectpunicalagin
dc.subjectpunicalin
dc.subjecttranscription factors
dc.subjectcell differentiation
dc.titlePUNICALAGIN AND PUNICALIN SUPPRESS THE ADIPOCYTE DIFFERENTIATION THROUGH THE TRANSCRIPTION FACTORS
dc.typeArticle

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