Photo-induced anti-inflammatory activities of chloro substituted subphthalocyanines on the mammalian macrophage in vitro

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dc.authoridAYAZ, FURKAN/0000-0003-0271-0594
dc.authoridInce, Mine/0000-0002-9164-0446
dc.contributor.authorAyaz, Furkan
dc.contributor.authorUgur, Naz
dc.contributor.authorOcakoglu, Kasim
dc.contributor.authorInce, Mine
dc.date.accessioned2025-03-17T12:26:01Z
dc.date.available2025-03-17T12:26:01Z
dc.date.issued2019
dc.departmentTarsus Üniversitesi
dc.description.abstractIn this study, a series of subphthalocyanines (SubPcs) derivatives were synthesized to generate unique immunomodulatory molecules that can be activated through photo-induction. Immunomodulatory agents have a great potential in medicine to manipulate the immune system according to our needs and prevent disease symptoms. Inflammation is one of these symptoms and macrophages play a crucial role in the generation of inflammatory responses. Being able to control the activity of these agents through photo-induction enables the fine tuning on their activities in a location specific and non-invasive manner with possibly minor side effects. Mammalian macrophages' pro-inflammatory activity was examined in the presence of our compounds as well as LPS as a danger mimic. These compounds exerted photo-induced anti-inflammatory activities on the macrophages. Number of Cl atoms was a defining factor in their photo-induced anti-inflammatory immunomodulatory efficiencies.
dc.identifier.doi10.1016/j.pdpdt.2019.02.002
dc.identifier.endpage503
dc.identifier.issn1572-1000
dc.identifier.issn1873-1597
dc.identifier.pmid30738845
dc.identifier.scopus2-s2.0-85061640203
dc.identifier.scopusqualityQ1
dc.identifier.startpage499
dc.identifier.urihttps://doi.org/10.1016/j.pdpdt.2019.02.002
dc.identifier.urihttps://hdl.handle.net/20.500.13099/1994
dc.identifier.volume25
dc.identifier.wosWOS:000465059600076
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier Science Bv
dc.relation.ispartofPhotodiagnosis and Photodynamic Therapy
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20250316
dc.subjectInflammation
dc.subjectmacrophages
dc.subjectimmunomodulatory agents
dc.subjectsuphthalocyanines
dc.subjectanti-inflammatory agents
dc.subjectPhotodynamic therapy
dc.titlePhoto-induced anti-inflammatory activities of chloro substituted subphthalocyanines on the mammalian macrophage in vitro
dc.typeArticle

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