Antimicrobial Effects of Nanostructured Rare-Earth-Based Orthovanadates

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dc.authoridTkachenko, Anton/0000-0002-1029-1636
dc.authoridYefimova, Svetlana/0000-0003-2092-1950
dc.authoridDizge, Nadir/0000-0002-7805-9315
dc.authoridMaksimchuk, Pavel/0000-0001-5448-1274
dc.contributor.authorGonca, Serpil
dc.contributor.authorYefimova, Svetlana
dc.contributor.authorDizge, Nadir
dc.contributor.authorTkachenko, Anton
dc.contributor.authorOzdemir, Sadin
dc.contributor.authorProkopiuk, Volodymyr
dc.contributor.authorKlochkov, Vladimir
dc.date.accessioned2025-03-17T12:27:39Z
dc.date.available2025-03-17T12:27:39Z
dc.date.issued2022
dc.departmentTarsus Üniversitesi
dc.description.abstractThe search for novel antimicrobial agents is of huge importance. Nanomaterials can come to the rescue in this case. The aim of this study was to assess the cytotoxicity and antimicrobial effects of rare-earth-based orthovanadate nanoparticles. The cytotoxicity against host cells and antimicrobial activity of LaVO4:Eu3+ and GdVO4:Eu3+ nanoparticles were analyzed. Effects of nanomaterials on fibroblasts were assessed by MTT, neutral red uptake and scratch assays. The antimicrobial effects were evaluated by the micro-dilution method estimating the minimum inhibitory concentration (MIC) of nanoparticles against various strains of microorganisms, DNA cleavage and biofilm inhibition. GdVO4:Eu3+ nanoparticles were found to be less toxic against eukaryotic cells compared with LaVO4:Eu3+. Both nanoparticles exhibited antimicrobial activity and the highest MIC values were 64 mg/L for E. hirae, E. faecalis and S. aureus shown by GdVO4:Eu3+ nanoparticles. Nanoparticles demonstrated good DNA cleavage activity and induction of double-strand breaks in supercoiled plasmid DNA even at the lowest concentrations used. Both nanoparticles showed the biofilm inhibition activity against S. aureus at 500 mg/L and reduced the microbial cell viability. Taken the results of host toxicity and antimicrobial activity studies, it can be assumed that GdVO4:Eu3+ nanoparticles are more promising antibacterial agents compared with LaVO4:Eu3+ nanoparticles.
dc.description.sponsorshipMinistry of Health of Ukraine [0121U110920]
dc.description.sponsorshipThe study was supported by the Ministry of Health of Ukraine using the funds provided by the state budget as a fragment of a research entitled Research of Efficiency, Mechanisms of Action and Safety of Use of Orthovanadate Nanoparticles of Rare Earth Elements for Optimization of Radiation Therapy in the Conditions of Oncopathology (state registration number 0121U110920).
dc.identifier.doi10.1007/s00284-022-02947-w
dc.identifier.issn0343-8651
dc.identifier.issn1432-0991
dc.identifier.issue9
dc.identifier.pmid35834046
dc.identifier.scopus2-s2.0-85134221032
dc.identifier.scopusqualityQ3
dc.identifier.urihttps://doi.org/10.1007/s00284-022-02947-w
dc.identifier.urihttps://hdl.handle.net/20.500.13099/2373
dc.identifier.volume79
dc.identifier.wosWOS:000825425400003
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringer
dc.relation.ispartofCurrent Microbiology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20250316
dc.subjectOxide Nanoparticles
dc.subjectAntibiotic-Resistance
dc.subjectToxicity
dc.subjectAntibacterial
dc.subjectAntioxidant
dc.subjectVanadium
dc.subjectGd
dc.titleAntimicrobial Effects of Nanostructured Rare-Earth-Based Orthovanadates
dc.typeArticle

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