Antimicrobial activity and cytotoxicity study of cerium oxide nanoparticles with two different sizes

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dc.authoridOcakoglu, Kasim/0000-0003-2807-0425
dc.authoridDizge, Nadir/0000-0002-7805-9315
dc.authoridYefimova, Svetlana/0000-0003-2092-1950
dc.authoridTkachenko, Anton/0000-0002-1029-1636
dc.contributor.authorYefimova, Svetlana
dc.contributor.authorKlochkov, Vladimir
dc.contributor.authorKavok, Nataliya
dc.contributor.authorTkachenko, Anton
dc.contributor.authorOnishchenko, Anatolii
dc.contributor.authorChumachenko, Tatyana
dc.contributor.authorDizge, Nadir
dc.date.accessioned2025-03-17T12:27:42Z
dc.date.available2025-03-17T12:27:42Z
dc.date.issued2023
dc.departmentTarsus Üniversitesi
dc.description.abstractThe control over bacterial diseases requires the development of novel antibacterial agents. The use of antibacterial nanomedicines is one of the strategies to tackle antibiotic resistance. The study was designed to assess the antimicrobial activity of cerium oxide (CeO2) nanoparticles (NP) of two different sizes (CeO2 NP1 [1-2 nm] and CeO2 NP2 [10-12 nm]) and their cytotoxicity towards eukaryotic cells. The antimicrobial activity, effects of nanoparticles on DNA cleavage, microbial cell viability, and biofilm formation inhibition were analyzed. The impact of cerium oxide nanoparticles on eryptosis of erythrocytes was estimated using annexin V staining by flow cytometry. The newly synthesized CeO2 NP1 and CeO2 NP2 displayed moderate antimicrobial activities. CeO2 NP1 and CeO2 NP2 exhibited single-strand DNA cleavage ability. CeO2 NPs were found to show 100% microbial cell viability inhibition at a concentration of 500 mg/L. In addition, CeO2 NP1 and CeO2 NP2 inhibited the biofilm formation of S. aureus and P. aeruginosa. Larger cerium oxide nanoparticles were found to be less toxic against erythrocytes compared with the smaller ones. CeO2 nanoparticles demonstrate moderate antimicrobial activity and low cytotoxicity towards erythrocytes, which make them promising antibacterial agents.
dc.description.sponsorshipNational Research Foundation of Ukraine [0120U105451]
dc.description.sponsorshipNational Research Foundation of Ukraine, Grant/Award Number: 0120U105451
dc.identifier.doi10.1002/jbm.b.35197
dc.identifier.endpage880
dc.identifier.issn1552-4973
dc.identifier.issn1552-4981
dc.identifier.issue4
dc.identifier.pmid36420776
dc.identifier.scopus2-s2.0-85143393186
dc.identifier.scopusqualityQ1
dc.identifier.startpage872
dc.identifier.urihttps://doi.org/10.1002/jbm.b.35197
dc.identifier.urihttps://hdl.handle.net/20.500.13099/2402
dc.identifier.volume111
dc.identifier.wosWOS:000890109500001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofJournal of Biomedical Materials Research Part B-Applied Biomaterials
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20250316
dc.subjectantimicrobial
dc.subjectbiofilm inhibition
dc.subjectcerium
dc.subjectDNA cleavage
dc.subjectmicrobial cell viability
dc.subjectnanoparticle
dc.titleAntimicrobial activity and cytotoxicity study of cerium oxide nanoparticles with two different sizes
dc.typeArticle

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