Novel Copper Bearing Schiff Bases with Photodynamic Anti-Inflammatory and Anti-Microbial Activities

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dc.authoridAYAZ, FURKAN/0000-0003-0271-0594
dc.contributor.authorAyaz, Furkan
dc.contributor.authorGonul, Ilyas
dc.contributor.authorDemirbag, Burcu
dc.contributor.authorOcakoglu, Kasim
dc.date.accessioned2025-03-17T12:27:30Z
dc.date.available2025-03-17T12:27:30Z
dc.date.issued2020
dc.departmentTarsus Üniversitesi
dc.description.abstractSchiff bases and their copper complexes have been previously studied for their anti-inflammatory, anti-tumor as well as anti-microbial activities. Schiff bases can be derivatized to gain photoluminiscence capacity. This property of the schiff bases enables the transfer of the electrons upon absorption of the light at a specific wavelength. In this study, we exploited this attribute of novel copper bearing schiff bases and tested their photodynamic biological activities. These compounds exerted photodynamic anti-inflammatory activities on the in vitro activated mammalian macrophages. Compared with salicylic acid control groups, these novel schiff bases had stronger activity which became more prominent with photo-induction. Moreover, they also had anti-microbial activity on gram negative bacteria E.coli and gram positive bacteria S.aureus.This anti-microbial activity was stronger than that of Neomycin on both bacterial strains. Our results suggest their potential use as anti-inflammatory and anti-microbial agents both in the dark as well as after photo-induction.
dc.identifier.doi10.1007/s12010-019-03223-7
dc.identifier.endpage727
dc.identifier.issn0273-2289
dc.identifier.issn1559-0291
dc.identifier.issue2
dc.identifier.pmid31853876
dc.identifier.scopus2-s2.0-85077081433
dc.identifier.scopusqualityQ2
dc.identifier.startpage716
dc.identifier.urihttps://doi.org/10.1007/s12010-019-03223-7
dc.identifier.urihttps://hdl.handle.net/20.500.13099/2295
dc.identifier.volume191
dc.identifier.wosWOS:000541559900018
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringer
dc.relation.ispartofApplied Biochemistry and Biotechnology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20250316
dc.subjectInflammation
dc.subjectMacrophage
dc.subjectImmunomodulation
dc.subjectAnti-inflammatory molecules
dc.subjectAnti-microbial activity
dc.titleNovel Copper Bearing Schiff Bases with Photodynamic Anti-Inflammatory and Anti-Microbial Activities
dc.typeArticle

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