Potential use of extracted flax seed mucilage in the construction of macroporous cryo-scaffolds

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dc.authoriddemir, didem/0000-0002-2977-2077
dc.contributor.authorDemir, Didem
dc.date.accessioned2025-03-17T12:25:43Z
dc.date.available2025-03-17T12:25:43Z
dc.date.issued2024
dc.departmentTarsus Üniversitesi
dc.description.abstractMucilage is a natural source of polysaccharides that has recently attracted attention for use in biomaterial production. It attracts attention with its easy and fast extraction, biocompatibility, high water retention capacity, and biodegradability. Although there are studies on the characterization of mucilage obtained from different plant sources, the interaction of this polymer with other polymers and its potential to form new biomaterials have not yet been sufficiently investigated. Based on this, in this study, the potential of mucilage extracted from flaxseed for the production of cryogels for tissue engineering applications was demonstrated. Firstly, yield, basic physicochemical properties, morphology, and surface charge-dependent isoelectric point determination studies were carried out for the characterization of the extracted mucilage. The successful preparation of mucilage was evaluated for the construction of cryo-scaffolds and 3D, spongy, and porous structures were obtained in the presence of chitosan and polyvinyl alcohol polymers. A heterogeneous morphology with interconnected macro and micro porosity in the range of approximately 85-115 m pore diameter was exhibited. Due to the high hydrophilic structure of the mucilage, which is attached to the structure with weak hydrogen bonds, the contact angle values of the scaffolds were obtained below 80 degrees and they showed the ability to absorb 1000 times their dry weight in approximately 30 min. As a preliminary optimization study for the evaluation of mucilage in cryogel formation, this work introduced a new construct to be developed as wound dressing scaffold for deep and chronic wounds.
dc.description.sponsorshipScientific Research Projects Unit of Tarsus University [OSB.22.003]
dc.description.sponsorshipThis study was supported by the Scientific Research Projects Unit of Tarsus University (OSB.22.003). The preliminary optimization results of this study were presented as a poster at EU-TERMIS 2023 (Manchester, UK) and then turned into a full-text format by scientifically enriching it with new experiments. The author would like to thank Dr Derya Yetkin for helping to perform the cell experiments and to thank Dr Onur Sevindik for mechanical analysis.
dc.identifier.doi10.1088/1748-605X/ad5bad
dc.identifier.issn1748-6041
dc.identifier.issn1748-605X
dc.identifier.issue5
dc.identifier.pmid38917835
dc.identifier.scopus2-s2.0-85197982951
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1088/1748-605X/ad5bad
dc.identifier.urihttps://hdl.handle.net/20.500.13099/1834
dc.identifier.volume19
dc.identifier.wosWOS:001262009800001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorDemir, Didem
dc.language.isoen
dc.publisherIop Publishing Ltd
dc.relation.ispartofBiomedical Materials
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20250316
dc.subjectmucilage
dc.subjectpolymer
dc.subjectcryogel
dc.subjectscaffold
dc.subjecttissue engineering
dc.titlePotential use of extracted flax seed mucilage in the construction of macroporous cryo-scaffolds
dc.typeArticle

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