Protective effect of myricetin, apigenin, and hesperidin pretreatments on cyclophosphamide-induced immunosuppression

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dc.authoridFrancik, Renata/0000-0002-7071-8072
dc.authoridBerkoz, Mehmet/0000-0003-4219-8054
dc.authoridADIYAMAN, ABDULLAH/0000-0002-3049-9813
dc.contributor.authorBerkoz, Mehmet
dc.contributor.authorYalin, Serap
dc.contributor.authorOzkan-Yilmaz, Ferbal
dc.contributor.authorOzluer-Hunt, Arzu
dc.contributor.authorKrosniak, Miroslaw
dc.contributor.authorFrancik, Renata
dc.contributor.authorYunusoglu, Oruc
dc.date.accessioned2025-03-17T12:25:47Z
dc.date.available2025-03-17T12:25:47Z
dc.date.issued2021
dc.departmentTarsus Üniversitesi
dc.description.abstractAim: Major side effects of cyclophosphamide administration are immunosuppression and myelosuppression. The immunomodulatory effects of plant bioactive compounds on chemotherapy drug-induced immunosuppression may have significant effects in cancer treatment. For this reason, we investigated the immunomodulatory effect of myricetin, apigenin, and hesperidin in cyclophosphamide-induced immunosuppression in rats. Methods: In our study, a total of 64 rats were used, and divided into eight equal groups. These groups were: control, cyclophosphamide, cyclophosphamide+myricetin (100mg/kg), cyclophosphamide+myricetin (200mg/kg), cyclophosphamide+apigenin (100mg/kg), cyclophosphamide+apigenin (200mg/kg), cyclophosphamide+hesperidin (100mg/kg), and cyclophosphamide+hesperidin (200mg/kg). Myricetin, apigenin, and hesperidin pretreatments were performed for 14d, while cyclophosphamide application (200mg/kg) was performed only on the 4th day of the study. Levels of humoral antibody production, quantitative hemolysis, macrophage phagocytosis, splenic lymphocyte proliferation, and natural killer cell cytotoxicity were determined. In addition, we measured pro-inflammatory cytokines, and followed lipid peroxidation and antioxidant markers and examined the histology of bone marrow, liver and spleen in all groups. Results: During cyclophosphamide treatment, all three phytochemicals increased the levels of humoral antibody production, quantitative hemolysis, macrophage phagocytosis, splenic lymphocyte proliferation, antioxidant markers, and natural killer cell cytotoxicity. Moreover, the agents decreased the levels of pro-inflammatory cytokines and mediators, reduced lipid peroxidation markers, and reduced tissue damage in liver, spleen, and bone marrow. Conclusion: Our study demonstrated that myricetin, apigenin, and hesperidin can reduce the immunosuppressive effect of cyclophosphamide by enhancing both innate and adaptive immune responses, and these compounds may be useful immunomodulatory agents during cancer chemotherapy.
dc.description.sponsorshipOffice of Scientific Research Projects of Van Yuzuncu Yil University [THD-2019-7853]
dc.description.sponsorshipThis research was financially supported by the Office of Scientific Research Projects of Van Yuzuncu Yil University under Grant number [THD-2019-7853].
dc.identifier.doi10.1080/08923973.2021.1916525
dc.identifier.endpage369
dc.identifier.issn0892-3973
dc.identifier.issn1532-2513
dc.identifier.issue3
dc.identifier.pmid33905277
dc.identifier.scopus2-s2.0-85105181963
dc.identifier.scopusqualityQ2
dc.identifier.startpage353
dc.identifier.urihttps://doi.org/10.1080/08923973.2021.1916525
dc.identifier.urihttps://hdl.handle.net/20.500.13099/1877
dc.identifier.volume43
dc.identifier.wosWOS:000663549900001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTaylor & Francis Ltd
dc.relation.ispartofImmunopharmacology and Immunotoxicology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20250316
dc.subjectCyclophosphamide
dc.subjectimmunomodulatory effect
dc.subjectmyricetin
dc.subjectapigenin
dc.subjecthesperidin
dc.titleProtective effect of myricetin, apigenin, and hesperidin pretreatments on cyclophosphamide-induced immunosuppression
dc.typeArticle

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