Cytotoxic and apoptotic potential of some coumarin and 2-amino-3-carbonitrile selenophene derivatives in prostate cancer

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dc.authoridErsatir, Mehmet/0000-0003-1077-0626
dc.contributor.authorYildirim, Metin
dc.contributor.authorErsatir, Mehmet
dc.contributor.authorArslan, Badel
dc.contributor.authorGiray, Elife Sultan
dc.date.accessioned2025-03-17T12:25:11Z
dc.date.available2025-03-17T12:25:11Z
dc.date.issued2021
dc.departmentTarsus Üniversitesi
dc.description.abstract3-acetyl coumarin derivatives (1a-d) are formed as a result of condensation of salicylaldehyde derivatives and ethyl acetoacetate and were converted into coumarin-selenophene hybrid compounds (2a-d) in the basic medium by modified Gewald reaction in the presence of malononitrile and selenium. Products are characterized by nuclear magnetic resonance (NMR). The prepared compounds are screened for their anticancer activity against DU-145 cell line. In addition, selected target compounds are evaluated for apoptosis and oxidative stress on DU-145 (prostate carcinoma) cell lines.
dc.identifier.doi10.3906/kim-2008-56
dc.identifier.endpage+
dc.identifier.issn1300-0527
dc.identifier.issue1
dc.identifier.pmid33737857
dc.identifier.scopus2-s2.0-85102255194
dc.identifier.scopusqualityQ3
dc.identifier.startpage192
dc.identifier.trdizinid525991
dc.identifier.urihttps://doi.org/10.3906/kim-2008-56
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/525991
dc.identifier.urihttps://hdl.handle.net/20.500.13099/1537
dc.identifier.volume45
dc.identifier.wosWOS:000639238600018
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTubitak Scientific & Technological Research Council Turkey
dc.relation.ispartofTurkish Journal of Chemistry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20250316
dc.subjectCoumarin
dc.subjectselenophene
dc.subjectantitumor agents
dc.subjectantioxidant activity
dc.subjectheterocycles
dc.titleCytotoxic and apoptotic potential of some coumarin and 2-amino-3-carbonitrile selenophene derivatives in prostate cancer
dc.typeArticle

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