Potential Protective Effects of Ruta Chalepensis L. Extracts Against Gentamicin-Induced Nephrotoxicity via Reduction on Apoptotic, DNA Damage and Oxidative Stress Markers in Mice

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dc.authoridErsatir, Mehmet/0000-0003-1077-0626
dc.contributor.authorYildirim, Metin
dc.contributor.authorErsatir, Mehmet
dc.contributor.authorDegirmenci, Ulas
dc.contributor.authorYigin, Akin
dc.contributor.authorUnal, Mustafa Boyraz
dc.contributor.authorGuldur, Muhammet Emin
dc.contributor.authorDemirkol, Onur
dc.date.accessioned2025-03-17T12:25:47Z
dc.date.available2025-03-17T12:25:47Z
dc.date.issued2023
dc.departmentTarsus Üniversitesi
dc.description.abstractIn this study, the protective effects of Ruta chalepensis L. extracts on the extent of tissue damage in gentamicin-induced nephrotoxicity have been investigated. Ruta chalepensis L. extracts were prepared by subcritical water and ultrasound-assisted organic solvent extraction methods. Protective activity of Ruta chalepensis L. extracts on Gentamicin-induced nephrotoxicity is investigated by apoptotic, DNA damage, oxidative stress markers and evaluating histopathological in kidney tissue of mice. Gentamicin significantly increased Caspase-3 and -8 activities, NO levels, serum creatinine and BUN, while 8-OHdG and MDA levels were significantly decreased with Ruta chalepensis L. extract treatment. In addition, Ruta chalepensis L. extracts treatment significantly increased CAT and SOD activities. Histopathological alterations in Gentamicin group were significantly diminished by application of Ruta chalepensis L. extracts. These results suggest that treatment with Ruta chalepensis L. extracts may ameliorate renal dysfunction and structural damage through the reduction of oxidative stress and apoptosis in the kidney.
dc.identifier.doi10.1080/09603123.2022.2105824
dc.identifier.endpage1545
dc.identifier.issn0960-3123
dc.identifier.issn1369-1619
dc.identifier.issue12
dc.identifier.pmid35917490
dc.identifier.scopus2-s2.0-85135240676
dc.identifier.scopusqualityQ1
dc.identifier.startpage1533
dc.identifier.urihttps://doi.org/10.1080/09603123.2022.2105824
dc.identifier.urihttps://hdl.handle.net/20.500.13099/1871
dc.identifier.volume33
dc.identifier.wosWOS:000835226100001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTaylor & Francis Ltd
dc.relation.ispartofInternational Journal of Environmental Health Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20250316
dc.subjectNephrotoxicity
dc.subjectgentamicin
dc.subjectoxidative stress
dc.subjectapoptosis
dc.subjectRuta chalepensis I
dc.titlePotential Protective Effects of Ruta Chalepensis L. Extracts Against Gentamicin-Induced Nephrotoxicity via Reduction on Apoptotic, DNA Damage and Oxidative Stress Markers in Mice
dc.typeArticle

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