Gelatin nanoparticles with tunable mechanical properties: effect of crosslinking time and loading

Basit Öğe Kaydı
dc.authoridWeiss, Agnes-Valencia/0000-0003-4767-7150
dc.authoridKhan, Saeed Ahmad/0000-0001-5606-2719
dc.authoridSchneider, Marc/0000-0002-9260-7357
dc.contributor.authorWeiss, Agnes -Valencia
dc.contributor.authorSchorr, Daniel
dc.contributor.authorMetz, Julia K.
dc.contributor.authorYildirim, Metin
dc.contributor.authorKhan, Saeed Ahmad
dc.contributor.authorSchneider, Marc
dc.date.accessioned2025-03-17T12:25:11Z
dc.date.available2025-03-17T12:25:11Z
dc.date.issued2022
dc.departmentTarsus Üniversitesi
dc.description.abstractTuning the elastic properties of nanoparticles intended to be used in drug delivery is of great interest. To this end, different poten-tial formulations are developed since the particle elasticity is affecting the in vitro and in vivo performance of the nanoparticles. Here we present a method to determine the elasticity of single gelatin nanoparticles (GNPs). Furthermore, we introduce the possi-bility of tuning the elastic properties of gelatin nanoparticles during their preparation through crosslinking time. Young's moduli from 5.48 to 14.26 MPa have been obtained. Additionally, the possibility to measure the elasticity of single nanoparticles revealed the influence of loading a macromolecular model drug (FITC-dextran) on the mechanical properties, which decreased with raising amounts of loaded drug. Loaded particles were significantly softer, with Young's moduli between 1.06 and 5.79 MPa for the same crosslinking time, than the blank GNPs. In contrast to this, lysozyme as a crosslinkable macromolecule did not influence the me-chanical properties. A good in vitro cell compatibility was found investigating blank GNPs and FITC-dextran-loaded GNPs in viability assays with the cancer cell line A549 and the human primary cell-derived hAELVi cell line.
dc.identifier.doi10.3762/bjnano.13.68
dc.identifier.endpage787
dc.identifier.issn2190-4286
dc.identifier.pmid36105690
dc.identifier.scopus2-s2.0-85137651502
dc.identifier.scopusqualityQ1
dc.identifier.startpage778
dc.identifier.urihttps://doi.org/10.3762/bjnano.13.68
dc.identifier.urihttps://hdl.handle.net/20.500.13099/1544
dc.identifier.volume13
dc.identifier.wosWOS:000854056900001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherBeilstein-Institut
dc.relation.ispartofBeilstein Journal of Nanotechnology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20250316
dc.subjectatomic force microscopy
dc.subjectdrug delivery
dc.subjectelasticity
dc.subjectgelatin nanoparticles
dc.subjectYoung?s modulus
dc.titleGelatin nanoparticles with tunable mechanical properties: effect of crosslinking time and loading
dc.typeArticle

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu