Investigating the Immunostimulatory and Immunomodulatory Effects of cis and trans Isomers of Ruthenium Polypyridyl Complexes on the Mammalian Macrophage-Like Cells

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dc.authoridcolak, suleyman gokhan/0000-0002-4978-1499
dc.authoridOcakoglu, Kasim/0000-0003-2807-0425
dc.authoridAYAZ, FURKAN/0000-0003-0271-0594
dc.contributor.authorAyaz, Furkan
dc.contributor.authorColak, Suleyman Gokhan
dc.contributor.authorOcakoglu, Kasim
dc.date.accessioned2025-03-17T12:27:41Z
dc.date.available2025-03-17T12:27:41Z
dc.date.issued2020
dc.departmentTarsus Üniversitesi
dc.description.abstractImmunomodulatory and immunostimulatory compounds are drug candidates for the regulation of the function of immune system cells to fight against disease conditions including cancer to autoimmunity as well as inflammatory disorders. Due to the electron transfer capacity of photosensitizers in solar cell structures, we hypothesized that they can also be used to regulate the immune system cells' functions possibly through interfering with their electron transfer related activities. We examined thecisandtransisomers (cis-Ru andtrans-Ru) of ruthenium polypyridyl complex on the activated macrophage-like cellsin vitro. Our results suggest immunostimulatory and positive immunomodulatory roles for the ruthenium complex.These compounds increased the production of tumor necrosis factor (TNF) pro-inflammatory cytokine by macrophage-like cells. Therefore, bothcisandtransisomers can be used as a new generation of adjuvant candidates in the vaccine formulations to further boost the activity of immune cells against the disease agent or antigen.
dc.description.sponsorshipMersin University BAP project [2020-1-AP5-3978]
dc.description.sponsorshipOur group greatly appreciate the support of Prof. Dr. Juan Anguita from CICBiogune . This study partially utilized from infrastructure support of Mersin University BAP project with ID number of 2020-1-AP5-3978. We would like to thank for their support as well.
dc.identifier.doi10.1002/slct.202002784
dc.identifier.endpage11653
dc.identifier.issn2365-6549
dc.identifier.issue37
dc.identifier.scopus2-s2.0-85092157213
dc.identifier.scopusqualityQ3
dc.identifier.startpage11648
dc.identifier.urihttps://doi.org/10.1002/slct.202002784
dc.identifier.urihttps://hdl.handle.net/20.500.13099/2391
dc.identifier.volume5
dc.identifier.wosWOS:000575923400029
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherWiley-V C H Verlag Gmbh
dc.relation.ispartofChemistryselect
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20250316
dc.subjectAdjuvants
dc.subjectBiological activity
dc.subjectBiological chemistry and chemical biology
dc.subjectInnate immunity
dc.subjectInflammation
dc.subjectMacrophages
dc.titleInvestigating the Immunostimulatory and Immunomodulatory Effects of cis and trans Isomers of Ruthenium Polypyridyl Complexes on the Mammalian Macrophage-Like Cells
dc.typeArticle

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