Investigating the Immunostimulatory and Immunomodulatory Effects of cis and trans Isomers of Ruthenium Polypyridyl Complexes on the Mammalian Macrophage-Like Cells
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Tarih
2020
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Wiley-V C H Verlag Gmbh
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Immunomodulatory and immunostimulatory compounds are drug candidates for the regulation of the function of immune system cells to fight against disease conditions including cancer to autoimmunity as well as inflammatory disorders. Due to the electron transfer capacity of photosensitizers in solar cell structures, we hypothesized that they can also be used to regulate the immune system cells' functions possibly through interfering with their electron transfer related activities. We examined thecisandtransisomers (cis-Ru andtrans-Ru) of ruthenium polypyridyl complex on the activated macrophage-like cellsin vitro. Our results suggest immunostimulatory and positive immunomodulatory roles for the ruthenium complex.These compounds increased the production of tumor necrosis factor (TNF) pro-inflammatory cytokine by macrophage-like cells. Therefore, bothcisandtransisomers can be used as a new generation of adjuvant candidates in the vaccine formulations to further boost the activity of immune cells against the disease agent or antigen.
Açıklama
Anahtar Kelimeler
Adjuvants, Biological activity, Biological chemistry and chemical biology, Innate immunity, Inflammation, Macrophages
Kaynak
Chemistryselect
WoS Q Değeri
Q3
Scopus Q Değeri
Q3
Cilt
5
Sayı
37
