Antiinflammatory photodynamic therapy potential of polyoxyethylene-substituted perylene diimide, nitrocatechol, and azo dye

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dc.authoridAYAZ, FURKAN/0000-0003-0271-0594
dc.contributor.authorHakli, Ozgul
dc.contributor.authorOcakoglu, Kasim
dc.contributor.authorAyaz, Furkan
dc.date.accessioned2025-03-17T12:25:11Z
dc.date.available2025-03-17T12:25:11Z
dc.date.issued2021
dc.departmentTarsus Üniversitesi
dc.description.abstractPhotodynamic therapy (PDT) applications enable light-controlled activation of drug candidates instead of their constitutive activities to prevent undesired side effects associated with their constant activities. A specific wavelength of light is utilized to enable electron mobility in the chemical structure, which results in differential activities that may alter cell viability and cellular functions. Canonical photodynamic therapy applications mostly focus on cytotoxicity-based antimicrobial and anticancer properties of the PDT agents. In this study, we focused on subtoxic concentrations of three different molecules containing polyoxyethylene group and examined their antiinflammatory activities on stimulated mammalian macrophages. Stimulated macrophages produce proinflammatory cytokines TNF and IL6. In the presence of a light source, our PDT agents were activated for 5 and 10 min during their application to the macrophages. Based on the ELISA results, the compounds had anti-inflammatory PDT activities. Trypan blue staining results suggest that these derivatives exerted their activities without leading to cytotoxicity. Our results suggest noncanonical PDT applications of these derivatives that can alter cellular activities without leading to cell death.
dc.identifier.doi10.3906/kim-2104-8
dc.identifier.endpage1760
dc.identifier.issn1300-0527
dc.identifier.issue6
dc.identifier.pmid38144584
dc.identifier.scopus2-s2.0-85122215325
dc.identifier.scopusqualityQ3
dc.identifier.startpage1752
dc.identifier.trdizinid527975
dc.identifier.urihttps://doi.org/10.3906/kim-2104-8
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/527975
dc.identifier.urihttps://hdl.handle.net/20.500.13099/1536
dc.identifier.volume45
dc.identifier.wosWOS:000729241000001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTubitak Scientific & Technological Research Council Turkey
dc.relation.ispartofTurkish Journal of Chemistry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20250316
dc.subjectInflammation
dc.subjectperylene
dc.subjectphotodynamic therapy
dc.subjectmacrophages
dc.subjectantiinflammatory compounds
dc.titleAntiinflammatory photodynamic therapy potential of polyoxyethylene-substituted perylene diimide, nitrocatechol, and azo dye
dc.typeArticle

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