Optimized microwave-assisted extraction and characterization of spray dried Luffa aegyptiaca nanomucilage: Physicochemical properties, biological activities, and anticancer efficacy against MCF-7 human breast cancer cells

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dc.contributor.authorMavai, Sayani
dc.contributor.authorBains, Aarti
dc.contributor.authorKumar, Ankur
dc.contributor.authorGoksen, Gulden
dc.contributor.authorDhull, Sanju Bala
dc.contributor.authorAli, Nemat
dc.contributor.authorShazly, Gamal A.
dc.date.accessioned2025-03-17T12:27:08Z
dc.date.available2025-03-17T12:27:08Z
dc.date.issued2025
dc.departmentTarsus Üniversitesi
dc.description.abstractMicrowave-assisted extraction conditions were optimized using response surface methodology to evaluate the effects of extraction parameters on the yield and carbohydrate content of Luffa aegyptiaca mucilage. The optimal extraction parameters were determined at 540 W for 2 min with a 1:20 (g/mL) ratio, yielding a maximum of 5.90 % (w/w) and comprising 63 % carbohydrate content, which includes glucose, galactose, maltose, mannose, and galacturonic acid, characterized by beta (1 -> 4) and beta (1 -> 6) glycosidic bonds. The nanomucilage exhibited a monomodal particle size distribution of 145.3 f 4.60 nm, high thermal stability (-1363.08 J/g), oil and water retention capacity, emulsifying ability (93.06 f 0.48 %), emulsifying stability (75.02 f 0.96 %), solubility (95.36 f 0.89 %), and foaming ability (93.06 f 0.48 %). Mucilage demonstrated potential in vitro anti-oxidant activity (2.05 f 0.10 %) against Caco-2 cells, anti-inflammatory activity during membrane stabilization (30.47 f 0.42 % to 70.46 f 0.31 %,) and protein denaturation (20.47 f 0.42 % to 78.39 f 0.40 %) assays and anticancer activity against human breast cancer cells (MCF-7), with growth inhibition of 100.5 f 12.45 %. Hence, this evaluation of Luffa aegyptiaca nanomucilage highlights its potential as a multifunctional biomaterial with significant applications in the healthcare industry.
dc.description.sponsorshipKing Saud University, Riyadh, Saudi Arabia [RSPD2025R1118]
dc.description.sponsorshipSupport of the central instrumental lab facility at Lovely Professional University, Phagwara, Punjab is gratefully acknowledged. Furthermore, the authors would like to extend their sincere appreciation to the Re-searchers Supporting Project Number (RSPD2025R1118) , King Saud University, Riyadh, Saudi Arabia for supporting this study.
dc.identifier.doi10.1016/j.ijbiomac.2025.139756
dc.identifier.issn0141-8130
dc.identifier.issn1879-0003
dc.identifier.pmid39798751
dc.identifier.scopus2-s2.0-85215972945
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1016/j.ijbiomac.2025.139756
dc.identifier.urihttps://hdl.handle.net/20.500.13099/2097
dc.identifier.volume299
dc.identifier.wosWOS:001412926200001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier
dc.relation.ispartofInternational Journal of Biological Macromolecules
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20250316
dc.subjectLuffa aegyptiaca fruit
dc.subjectOptimization
dc.subjectMicrowave-assisted extraction
dc.subjectNanomucilage
dc.subjectAntioxidant
dc.subjectAnti-inflammatory
dc.subjectAnticancer
dc.titleOptimized microwave-assisted extraction and characterization of spray dried Luffa aegyptiaca nanomucilage: Physicochemical properties, biological activities, and anticancer efficacy against MCF-7 human breast cancer cells
dc.typeArticle

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