The Effect of Sitagliptin and Exenatide on Insulin, Insulin Receptor and Insulin Receptor Substrate Gene Expression in Diabetic Rats

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dc.authoridComelekoglu, Ulku/0000-0001-8060-6333
dc.contributor.authorYildirim, M.
dc.contributor.authorMistik, O. Agtas
dc.contributor.authorYalin, A. E.
dc.contributor.authorComelekoglu, U.
dc.contributor.authorBerkoz, M.
dc.contributor.authorArpaci, R. Bozdogan
dc.contributor.authorYalin, S.
dc.date.accessioned2025-03-17T12:25:35Z
dc.date.available2025-03-17T12:25:35Z
dc.date.issued2023
dc.departmentTarsus Üniversitesi
dc.description.abstractDiabetes mellitus is a chronic metabolic disorder characterized by persistent hyperglycemia that results from abnormal secretion of insulin, inappropriate action of insulin or both. The aim of this study is to determine the effects of exenatide and sitagliptin treatment on the expression of insulin (INS-1), insulin receptor (INSR) and insulin receptor substrate (IRS-1) genes. In this study streptozotocin-induced diabetic rats were treated with sitagliptin (10 mg/kg) and exenatide (0.1 mu g/kg) for 15 days. We measured INS-1, INSR and IRS-1 gene expression levels and examined the histology of pancreatic tissues in all groups. Exenatide and sitagliptin treatment increased gene expression levels of INS-1, INSR and IRS-1.
dc.description.sponsorshipMersin University Scientific Research Projects, Mersin, Turkey [2017-2-AP3-2532]
dc.description.sponsorshipThis study was supported by funding from the Mersin University Scientific Research Projects (Project no. 2017-2-AP3-2532), Mersin, Turkey.
dc.identifier.doi10.1134/S1068162023030275
dc.identifier.endpage615
dc.identifier.issn1068-1620
dc.identifier.issn1608-330X
dc.identifier.issue3
dc.identifier.scopus2-s2.0-85159100905
dc.identifier.scopusqualityQ4
dc.identifier.startpage610
dc.identifier.urihttps://doi.org/10.1134/S1068162023030275
dc.identifier.urihttps://hdl.handle.net/20.500.13099/1768
dc.identifier.volume49
dc.identifier.wosWOS:000986155200008
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherMaik Nauka/Interperiodica/Springer
dc.relation.ispartofRussian Journal of Bioorganic Chemistry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20250316
dc.subjectexenatide
dc.subjectsitagliptin
dc.subjectdiabetes
dc.subjectinsulin
dc.subjectgene expression
dc.titleThe Effect of Sitagliptin and Exenatide on Insulin, Insulin Receptor and Insulin Receptor Substrate Gene Expression in Diabetic Rats
dc.typeArticle

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