Design of gelatin cryogel scaffolds with the ability to release simvastatin for potential bone tissue engineering applications

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dc.authoriddemir, didem/0000-0002-2977-2077
dc.authoridBolgen, Nimet/0000-0003-3162-0803
dc.contributor.authorYaman, Suzan Melis
dc.contributor.authorDemir, Didem
dc.contributor.authorBolgen, Nimet
dc.date.accessioned2025-03-17T12:25:43Z
dc.date.available2025-03-17T12:25:43Z
dc.date.issued2024
dc.departmentTarsus Üniversitesi
dc.description.abstractTissue engineering aims to improve or restore damaged tissues by using scaffolds, cells and bioactive agents. In tissue engineering, one of the most important concepts is the scaffold because it has a key role in keeping up and promoting the growth of the cells. It is also desirable to be able to load these scaffolds with drugs that induce tissue regeneration/formation. Based on this, in our study, gelatin cryogel scaffolds were developed for potential bone tissue engineering applications and simvastatin loading and release studies were performed. Simvastatin is lipoliphic in nature and this form is called inactive simvastatin (SV). It is modified to be in hydrophilic form and converted to the active form (SVA). For our study's drug loading and release process, simvastatin was used in both inactive and active forms. The blank cryogels and drug-loaded cryogels were prepared at different glutaraldehyde concentrations (1, 2, and 3%). The effect of the crosslinking agent and the amount of drug loaded were discussed with morphological and physicochemical analysis. As the glutaraldehyde concentration increased gradually, the pores size of the cryogels decreased and the swelling ratio decreased. For the release profile of simvastatin in both forms, we can say that it depended on the form (lipophilic and hydrophilic) of the loaded simvastatin.
dc.description.sponsorshipMersin niversitesihttp://dx.doi.org/10.13039/501100004172 ['2016-2-TP2-1898]; Scientific Research Projects Coordination Unit of Mersin University
dc.description.sponsorshipThe authors would like to thank the Scientific Research Projects Coordination Unit of Mersin University for supporting this research with the project numbered '2016-2-TP2-1898'
dc.identifier.doi10.1088/1748-605X/ad651e
dc.identifier.issn1748-6041
dc.identifier.issn1748-605X
dc.identifier.issue5
dc.identifier.pmid39025109
dc.identifier.scopus2-s2.0-85199696083
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1088/1748-605X/ad651e
dc.identifier.urihttps://hdl.handle.net/20.500.13099/1833
dc.identifier.volume19
dc.identifier.wosWOS:001276861300001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherIop Publishing Ltd
dc.relation.ispartofBiomedical Materials
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20250316
dc.subjectgelatin
dc.subjectsimvastatin
dc.subjectcryogel
dc.subjectdrug delivery
dc.subjectbone tissue engineering
dc.titleDesign of gelatin cryogel scaffolds with the ability to release simvastatin for potential bone tissue engineering applications
dc.typeArticle

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