Differential Immunomodulatory Activities of Schiff Base Complexes Depending on their Metal Conjugation

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dc.authoridAYAZ, FURKAN/0000-0003-0271-0594
dc.contributor.authorAyaz, Furkan
dc.contributor.authorGonul, Ilyas
dc.contributor.authorDemirbag, Burcu
dc.contributor.authorOcakoglu, Kasim
dc.date.accessioned2025-03-17T12:27:37Z
dc.date.available2025-03-17T12:27:37Z
dc.date.issued2019
dc.departmentTarsus Üniversitesi
dc.description.abstractImmunomodulatory compounds have become crucial with advances in immunotherapy. Using our own immune system cells, we can direct the immune cell function and develop desired response against a certain threat. Immunotherapy applications have been suggested against tumors, autoimmune disorders, and infectious diseases. Vaccination can be considered as one of the best known example of immunotherapy. Infectious agent's signature molecular structures are introduced to the immune cells together with the adjuvants that further activate the immune cells to mount a proper immune response and memory. Immunotherapy and vaccine formulations are in constant need of a library of immunomodulatory reagents that can be applied depending on the target. In order to expand the number of immunomodulatory reagents that can find medicinal applications, our group has been testing unique chemical structures on the immune system cells, especially macrophages. Schiff base complexes are known for their anti-inflammatory and antimicrobial activities. In this study, we used previously characterized Schiff base complexes with different metal conjugations. These molecules had differential immunostimulatory and immunomodulatory potentials on macrophages in vitro depending on the type of the conjugated metal. After light exposure, these complexes changed their characteristics and became powerful anti-inflammatory complexes. Due to their possible antimicrobial potentials, we also tested their activities against gram negative and gram positive bacteria. All of the complexes exerted antimicrobial activities which were not light responsive. Here, we present Schiff base complexes with differential immunostimulatory and immunomodulatory activities that can also efficiently eliminate gram positive and gram negative bacteria. Upon photo activation, they block the production of inflammatory TNF alpha cytokine. Therefore, together with the light, they can be used to treat bacterial infections associated with damaging inflammation.
dc.identifier.doi10.1007/s10753-019-01050-w
dc.identifier.endpage1885
dc.identifier.issn0360-3997
dc.identifier.issn1573-2576
dc.identifier.issue5
dc.identifier.pmid31267275
dc.identifier.scopus2-s2.0-85068846462
dc.identifier.scopusqualityQ1
dc.identifier.startpage1878
dc.identifier.urihttps://doi.org/10.1007/s10753-019-01050-w
dc.identifier.urihttps://hdl.handle.net/20.500.13099/2352
dc.identifier.volume42
dc.identifier.wosWOS:000483660100033
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringer/Plenum Publishers
dc.relation.ispartofInflammation
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20250316
dc.subjectimmunomodulation
dc.subjectmacrophages
dc.subjectPDT
dc.subjectantimicrobial activity
dc.subjectinflammation
dc.titleDifferential Immunomodulatory Activities of Schiff Base Complexes Depending on their Metal Conjugation
dc.typeArticle

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