Oxidative stress and metabolic diseases: Relevance and therapeutic strategies

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dc.authoridAli, Murtaza/0000-0002-5020-7398
dc.authoridAli, Anwar/0000-0003-3169-1804
dc.authoridGoksen, Gulden/0000-0002-5432-7936
dc.contributor.authorManzoor, Muhammad Faisal
dc.contributor.authorArif, Zaira
dc.contributor.authorKabir, Asifa
dc.contributor.authorMehmood, Iqra
dc.contributor.authorMunir, Danial
dc.contributor.authorRazzaq, Aqsa
dc.contributor.authorAli, Anwar
dc.date.accessioned2025-03-17T12:25:18Z
dc.date.available2025-03-17T12:25:18Z
dc.date.issued2022
dc.departmentTarsus Üniversitesi
dc.description.abstractMetabolic syndrome (MS) is a prominent cause of death worldwide, posing a threat to the global economy and public health. A mechanism that causes the oxidation of low-density lipoproteins (LDL) is associated with metabolic abnormalities. Various processes are involved in oxidative stress (OS) of lipoprotein. Although the concept of the syndrome has been fiercely debated, this confluence of risk factors is associated with a higher chance of acquiring type 2 diabetes mellitus (T2DM) and atherosclerosis. Insulin resistance has been found to play a significant role in the progression of these metabolism-associated conditions. It causes lipid profile abnormalities, including greater sensitivity to lipid peroxidation, contributing to the increased prevalence of T2DM and atherosclerosis. This review aims to cover the most recent scientific developments in dietary OS, the consequence of metabolic disorders, and their most significant clinical manifestations (T2DM and atherosclerosis). It will also emphasize the effects of dietary approaches in alleviating OS in MS.
dc.description.sponsorshipRomanian National Authority for Scientific Research and Innovation, CNCS-UEFISCDI within PNCDI III [PN-III-P2-2.1-PED-2019-1723, PFE 14]; Guangdong Provincial Key Laboratory of Intelligent Food Manufacturing, Foshan University, Foshan, China [2022B1212010015]
dc.description.sponsorshipThis study was supported by a grant from the Romanian National Authority for Scientific Research and Innovation, CNCS-UEFISCDI, Project Number PN-III-P2-2.1-PED-2019-1723 and PFE 14, within PNCDI III. The authors also want to acknowledge the support of Guangdong Provincial Key Laboratory of Intelligent Food Manufacturing, Foshan University, Foshan 528225, China (Project ID:2022B1212010015).
dc.identifier.doi10.3389/fnut.2022.994309
dc.identifier.issn2296-861X
dc.identifier.pmid36324618
dc.identifier.scopus2-s2.0-85141000073
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.3389/fnut.2022.994309
dc.identifier.urihttps://hdl.handle.net/20.500.13099/1606
dc.identifier.volume9
dc.identifier.wosWOS:000878192300001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherFrontiers Media Sa
dc.relation.ispartofFrontiers in Nutrition
dc.relation.publicationcategoryDiğer
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20250316
dc.subjectoxidative stress
dc.subjectmetabolic diseases
dc.subjecta burden on health
dc.subjecttherapeutic approaches
dc.subjectLDL
dc.titleOxidative stress and metabolic diseases: Relevance and therapeutic strategies
dc.typeReview

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