Water-Based Synthesis of Copper Chalcogenide Structures and Their Photodynamic Immunomodulatory Activities on Mammalian Macrophages

Basit Öğe Kaydı
dc.authoridcolak, suleyman gokhan/0000-0002-4978-1499
dc.authoridAYAZ, FURKAN/0000-0003-0271-0594
dc.authoridOcakoglu, Kasim/0000-0003-2807-0425
dc.contributor.authorAyaz, Furkan
dc.contributor.authorColak, Suleyman Gokhan
dc.contributor.authorOcakoglu, Kasim
dc.date.accessioned2025-03-17T12:27:30Z
dc.date.available2025-03-17T12:27:30Z
dc.date.issued2022
dc.departmentTarsus Üniversitesi
dc.description.abstractGeneration of novel and versatile immunomodulatory agents that could suppress excessive inflammation has been crucial to fight against chronic inflammatory and autoimmune disorders. Immunomodulatory agents regulate the function of immune system cells to manage their activities. Current therapy regimens for the inflammatory and autoimmune disorders rely on immunomodulatory drug molecules but they are also associated with unwanted and severe side effects. In order to prevent the side effects associated with drug molecules, the field should generate novel immunomodulatory drug candidates and further test them. Moreover, the generation of photodynamic immunomodulatory molecules would also decrease possible side effects. Photodynamic activation enables specific and localized activation of the active ingredients upon exposure to a certain wavelength of light. In our study, we generated copper-based chalcogenide structures in gel and nanoparticle form by using a water-based method so that they are more biocompatible.After their chemical characterization, they were tested on mammalian macrophages in vitro. Our results suggest that these molecules were anti-inflammatory in dark conditions and their anti-inflammatory potentials significantly increased upon xenon light treatment. We are presenting novel photodynamic immunomodulatory agents that can be used to suppress excessive inflammation in disease conditions that have been associated with excessive inflammation.
dc.description.sponsorshipMersin University BAP project [2020-1-AP5-3978]
dc.description.sponsorshipThis study is partially utilized from infrastructure support of Mersin University BAP project (2020-1-AP5-3978).
dc.identifier.doi10.1007/s12010-022-03942-4
dc.identifier.endpage3688
dc.identifier.issn0273-2289
dc.identifier.issn1559-0291
dc.identifier.issue8
dc.identifier.pmid35488952
dc.identifier.scopus2-s2.0-85129157465
dc.identifier.scopusqualityQ2
dc.identifier.startpage3677
dc.identifier.urihttps://doi.org/10.1007/s12010-022-03942-4
dc.identifier.urihttps://hdl.handle.net/20.500.13099/2293
dc.identifier.volume194
dc.identifier.wosWOS:000789072400001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringer
dc.relation.ispartofApplied Biochemistry and Biotechnology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20250316
dc.subjectChalcogenide
dc.subjectCZTS
dc.subjectMacrophages
dc.subjectPhotodynamic therapy
dc.subjectInflammation
dc.subjectImmunomodulatory drugs
dc.titleWater-Based Synthesis of Copper Chalcogenide Structures and Their Photodynamic Immunomodulatory Activities on Mammalian Macrophages
dc.typeArticle

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu