A Review for Uncovering the Protein-Nanoparticle Alliance: Implications of the Protein Corona for Biomedical Applications

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dc.authoridOdabasi, Mehmet/0000-0002-2589-9919
dc.authoridGuel, Desiree/0000-0002-2446-5756
dc.contributor.authorOnal Acet, Burcu
dc.contributor.authorGul, Desiree
dc.contributor.authorStauber, Roland H.
dc.contributor.authorOdabasi, Mehmet
dc.contributor.authorAcet, Omur
dc.date.accessioned2025-03-17T12:25:13Z
dc.date.available2025-03-17T12:25:13Z
dc.date.issued2024
dc.departmentTarsus Üniversitesi
dc.description.abstractUnderstanding both the physicochemical and biological interactions of nanoparticles is mandatory for the biomedical application of nanomaterials. By binding proteins, nanoparticles acquire new surface identities in biological fluids, the protein corona. Various studies have revealed the dynamic structure and nano-bio interactions of the protein corona. The binding of proteins not only imparts new surface identities to nanoparticles in biological fluids but also significantly influences their bioactivity, stability, and targeting specificity. Interestingly, recent endeavors have been undertaken to harness the potential of the protein corona instead of evading its presence. Exploitation of this 'protein-nanoparticle alliance' has significant potential to change the field of nanomedicine. Here, we present a thorough examination of the latest research on protein corona, encompassing its formation, dynamics, recent developments, and diverse bioapplications. Furthermore, we also aim to explore the interactions at the nano-bio interface, paving the way for innovative strategies to advance the application potential of the protein corona. By addressing challenges and promises in controlling protein corona formation, this review provides insights into the evolving landscape of the 'protein-nanoparticle alliance' and highlights emerging.
dc.description.sponsorshipBrigitte and Dr. Konstanze Wegener Stiftung; [90]
dc.description.sponsorshipThe work of DG is funded by the Brigitte and Dr. Konstanze Wegener Stiftung (project #90).
dc.identifier.doi10.3390/nano14100823
dc.identifier.issn2079-4991
dc.identifier.issue10
dc.identifier.pmid38786780
dc.identifier.scopus2-s2.0-85194255706
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.3390/nano14100823
dc.identifier.urihttps://hdl.handle.net/20.500.13099/1567
dc.identifier.volume14
dc.identifier.wosWOS:001231252100001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherMdpi
dc.relation.ispartofNanomaterials
dc.relation.publicationcategoryDiğer
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20250316
dc.subjectprotein corona
dc.subjectnanoparticle
dc.subjectnanoparticle-protein interactions
dc.subjectbioapplications
dc.subjectexosomes
dc.subjectviruses
dc.titleA Review for Uncovering the Protein-Nanoparticle Alliance: Implications of the Protein Corona for Biomedical Applications
dc.typeReview

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