Onosma rutila (Boraginaceae) Plant Extract: Chemical Composition, Biological Analysis, and Film Forming Potential With Polymers

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dc.authoriddemir, didem/0000-0002-2977-2077
dc.authoridTurunc, Ersan/0000-0001-6412-9020
dc.contributor.authorBinzet, Riza
dc.contributor.authorBinzet, Gun
dc.contributor.authorTurunc, Ersan
dc.contributor.authorCevik, Pinar Kuce
dc.contributor.authorDemir, Didem
dc.contributor.authorArslan, Hakan
dc.date.accessioned2025-03-18T12:27:46Z
dc.date.available2025-03-17T12:27:46Z
dc.date.issued2025
dc.departmentTarsus Üniversitesi
dc.description.abstractThis study aimed to integrate the ethanolic extract obtained from the aerial parts of endemic Onosma rutila as a new bioactive ingredient into polymeric films and to produce biofunctional composite thin films for use in biomedical applications. Initially, the definition of the plant extract was carried out in terms of chemical composition and biological activities. The main component of the extract was revealed as 9,12-octadecadienoic acid (15.90%). Antimicrobial activity was evaluated against a total of five microorganisms by the well diffusion method and microdilution technique. MIC99 results showed the lowest inhibition against Candida albicans, suggesting a stronger antifungal effect than antibacterial activity. Also, the 2,2-diphenyl-1-picrylhydrazyl scavenging activity of O. rutila, ascorbic acid, and butylated hydroxytoluene at 500 mu g/mL showed values of 87.63, 90.13, and 46.82%, respectively. In the next phase, the extract, which was revealed to be an effective biological agent, was incorporated into the polymer solutions prepared based on chitosan and polyvinyl alcohol at different ratios to produce a series of thin films. For application purposes, the thin films' chemical compositions, water retention capacities, and morphological properties were determined and their potential for use as wound dressing material was evaluated.
dc.description.sponsorshipMersin niversitesi [BAP 2018-2-AP4-3013]; Research Fund of Mersin University in Turkey; Mersin University Advanced Technology Education, Research and Application Center (MEITAM)
dc.description.sponsorshipThis study was supported by the Research Fund of Mersin University in Turkey with Project Number: BAP 2018-2-AP4-3013. The authors would also like to thank Mersin University Advanced Technology Education, Research and Application Center (MEITAM).
dc.identifier.doi10.1002/cbdv.202403403
dc.identifier.issn1612-1872
dc.identifier.issn1612-1880
dc.identifier.pmid39923245
dc.identifier.scopus2-s2.0-85217247012
dc.identifier.scopusqualityQ3
dc.identifier.urihttps://doi.org/10.1002/cbdv.202403403
dc.identifier.urihttps://hdl.handle.net/20.500.13099/2419
dc.identifier.wosWOS:001418963800001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWiley-V C H Verlag Gmbh
dc.relation.ispartofChemistry & Biodiversity
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20250316
dc.subjectantimicrobial activity
dc.subjectantioxidant activity
dc.subjectBoraginaceae
dc.subjectOnosma rutila
dc.subjectthin film
dc.subjectwound dressing
dc.titleOnosma rutila (Boraginaceae) Plant Extract: Chemical Composition, Biological Analysis, and Film Forming Potential With Polymers
dc.typeArticle

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