Non-canonical anti-cancer, anti-metastatic, anti-angiogenic and immunomodulatory PDT potentials of water soluble phthalocyanine derivatives with imidazole groups and their intracellular mechanism of action

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dc.authoridAYAZ, FURKAN/0000-0003-0271-0594
dc.authoridDEMIRCIOGLU, Perihan Kubra/0000-0001-9077-5990
dc.authoridYUZER, ABDULCELIL/0000-0002-2287-4126
dc.contributor.authorAyaz, Furkan
dc.contributor.authorYetkin, Derya
dc.contributor.authorYuzer, Abdulcelil
dc.contributor.authorDemircioglu, Kubra
dc.contributor.authorInce, Mine
dc.date.accessioned2025-03-17T12:26:00Z
dc.date.available2025-03-17T12:26:00Z
dc.date.issued2022
dc.departmentTarsus Üniversitesi
dc.description.abstractCancer is currently a leading health issue globally. Chemotherapy is a prominent treatment method but due to undesired side effects t, there has been a need for novel less toxic approaches. Photodynamic therapy may be listed among the alternatives for efficient and potentially less detrimental applications of cancer therapy. Canonical photodynamic therapy (PDT) approach requires a light source with a specific wavelength of light, a nontoxic photosensitizer and molecular oxygen. PDT creates the desired effect by the photochemical reaction created through interaction of these components to create reactive oxygen species that will act on the cancer cells to enable anti-cancer activities. In our study we focus on non-canonical PDT application. In this approach we are not only aiming to eliminate cancer cells in the environment but also test the anti-metastatic, anti-angiogenic and possible immunomodulatory activities of the novel photosensitizers. Moreover, in our approach, we studied the intracellular pathways that are crucial for carcinogenesis, cell cycle, apoptosis, angiogenesis, metastasis and immune function to decipher the mechanism of the action for each compound. Reactive oxygen species based explanation was not valid in our study, hence it brings out a non canonical approach to PDT applications. Our results suggests that Phthalocyanine derivatives with imidazole groups can be effectively used against lung, colon, breast and prostate cancer while differentially effecting metastasis, angiogenesis, cell cycle, apoptosis and immune system cell's activities. Based on the results, PDT application of these phthalocyanine derivatives can be an effective treatment option to replace chemotherapy to minimize the potential side effects.
dc.description.sponsorshipTUBITAK 1001 Program [119Z354]
dc.description.sponsorshipThis study was supported by TUBITAK 1001 Program with 119Z354 ID number. We would like to present our sincere gratitude for their support.
dc.identifier.doi10.1016/j.pdpdt.2022.103035
dc.identifier.issn1572-1000
dc.identifier.issn1873-1597
dc.identifier.pmid35905830
dc.identifier.scopus2-s2.0-85135949148
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1016/j.pdpdt.2022.103035
dc.identifier.urihttps://hdl.handle.net/20.500.13099/1988
dc.identifier.volume39
dc.identifier.wosWOS:000911779700009
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier
dc.relation.ispartofPhotodiagnosis and Photodynamic Therapy
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20250316
dc.subjectPhthalocyanine
dc.subjectPhotodynamic therapy
dc.subjectCancer
dc.subjectAngiogenesis
dc.subjectMetastasis
dc.subjectImmune system
dc.subjectImmunomodulatory effect
dc.titleNon-canonical anti-cancer, anti-metastatic, anti-angiogenic and immunomodulatory PDT potentials of water soluble phthalocyanine derivatives with imidazole groups and their intracellular mechanism of action
dc.typeArticle

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