Antibacterial and antioxidant activity of gold and silver nanoparticles in dextran–polyacrylamide copolymers

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dc.authoridhttps://orcid.org/0000-0003-2807-0425
dc.authorscopusid36088420200
dc.authorwosidAAM-8078-2020
dc.contributor.authorTkachenko, Anton
dc.contributor.authorÖzdemir, Sadin
dc.contributor.authorTollu, Gülşah
dc.contributor.authorDizge, Nadir
dc.contributor.authorOcakoglu, Kasım
dc.contributor.authorProkopiuk, Volodymyr
dc.contributor.authorOnishchenko, Anatolii
dc.contributor.author?humachenko, Vasyl
dc.contributor.authorVirych, Pavlo
dc.contributor.authorPavlenko, Vadym
dc.contributor.authorKutsevol, Nataliya
dc.date.accessioned2024-08-06T12:05:08Z
dc.date.available2024-08-06T12:05:08Z
dc.date.issued2024
dc.departmentFakülteler, Mühendislik Fakültesi, Mühendislik Temel Bilimleri Bölümü
dc.description.abstractSearch for new antimicrobial agents is of great significance due to the issue of antimicrobial resistance, which nowadays has become more important than many diseases. The aim of this study was to evaluate the toxicity and biological effects of a dextran-graft-polyacrylamide (D-PAA) polymer-nanocarrier with/without silver or gold nanoparticles (AgNPs/D-PAA and AuNPs/D-PAA, respectively) to analyze their potential to replace or supplement conventional antibiotic therapy. The toxicity of nanocomplexes against eukaryotic cells was assessed on primary dermal fibroblasts using scratch, micronucleus and proliferation assays. DPPH (2,2-diphenyl-1-picrylhydrazylradical) assay was used to evaluate the antioxidant capacity of D-PAA, AgNPs/D-PAA and AuNPs/D-PAA. DNA cleavage, antimicrobial and biofilm inhibition effects of nanocomplexes were investigated. Nanocomplexes were found to be of moderate toxicity against fibroblasts with no genotoxicity observed. AgNPs/D-PAA reduced motility and proliferation at lower concentrations compared with the other studied nanomaterials. AgNPs/D-PAA and AuNPs/D-PAA showed radical scavenging capacities in a dose-dependent manner. The antimicrobial activity of AgNPs/D-PAA against various bacteria was found to be much higher compared to D-PAA and AuNPs/D-PAA, especially against E. hirae, E. faecalis and S. aureus, respectively. D-PAA, AgNPs/D-PAA and AuNPs/D-PAA showed DNA-cleaving and biofilm inhibitory activity, while AgNPs/D-PAA displayed the highest anti-biofilm activity. AgNPs/D-PAA and AuNPs/D-PAA were characterized by good antimicrobial activity. According to the findings of the study, AgNPs/D-PAA and AuNPs/D-PAA can be evaluated as alternatives for the preparation of new antimicrobial agents, the fight against biofilms, sterilization and disinfection processes. Our findings confirm the versatility of nanosystems based on dextran-polyacrylamide polymers and indicate that AgNPs/D-PAA and AuNPs/D-PAA can be evaluated as alternatives for the preparation of novel antimicrobial agents.
dc.identifier.citationTkachenko, A., Özdemir, S., Tollu, G. , Antibacterial and antioxidant activity of gold and silver nanoparticles in dextran–polyacrylamide copolymers. Biometals 37, 115–130 (2024). https://doi.org/10.1007/s10534-023-00532-7
dc.identifier.doi10.1007/s10534-023-00532-7
dc.identifier.endpage130en_US
dc.identifier.issn0966-0844
dc.identifier.issn1572-8773
dc.identifier.issue1en_US
dc.identifier.pmid37651060
dc.identifier.scopus2-s2.0-85169165436
dc.identifier.scopusqualityQ1
dc.identifier.startpage115en_US
dc.identifier.urihttps://hdl.handle.net/20.500.13099/329
dc.identifier.volume37en_US
dc.identifier.wosWOS:001062549100002
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorOcak, Kasım
dc.language.isoen
dc.publisherSpringer Link
dc.relation.ispartofBioMetals
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAntimicrobial activity
dc.subjectAntioxidant
dc.subjectDNA cleavage
dc.subjectGold nanoparticles
dc.subjectSilver nanoparticles
dc.titleAntibacterial and antioxidant activity of gold and silver nanoparticles in dextran–polyacrylamide copolymers
dc.typeArticle

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