Antibacterial and antioxidant activity of gold and silver nanoparticles in dextran–polyacrylamide copolymers

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dc.authoridhttps://orcid.org/0000-0003-2807-0425en_US
dc.authorscopusid36088420200en_US
dc.authorwosidAAM-8078-2020en_US
dc.contributor.authorTkachenko, Anton
dc.contributor.authorÖzdemir, Sadin
dc.contributor.authorTollu, Gülşah
dc.contributor.authorDizge, Nadir
dc.contributor.authorOcakoglu, Kasım
dc.contributor.authorProkopiuk, Volodymyr
dc.contributor.authorOnishchenko, Anatolii
dc.contributor.authorСhumachenko, Vasyl
dc.contributor.authorVirych, Pavlo
dc.contributor.authorPavlenko, Vadym
dc.contributor.authorKutsevol, Nataliya
dc.date.accessioned2024-08-06T12:05:08Z
dc.date.available2024-08-06T12:05:08Z
dc.date.issued2024en_US
dc.departmentFakülteler, Mühendislik Fakültesi, Mühendislik Temel Bilimleri Bölümüen_US
dc.description.abstractSearch for new antimicrobial agents is of great significance due to the issue of antimicrobial resistance, which nowadays has become more important than many diseases. The aim of this study was to evaluate the toxicity and biological effects of a dextran-graft-polyacrylamide (D-PAA) polymer-nanocarrier with/without silver or gold nanoparticles (AgNPs/D-PAA and AuNPs/D-PAA, respectively) to analyze their potential to replace or supplement conventional antibiotic therapy. The toxicity of nanocomplexes against eukaryotic cells was assessed on primary dermal fibroblasts using scratch, micronucleus and proliferation assays. DPPH (2,2-diphenyl-1-picrylhydrazylradical) assay was used to evaluate the antioxidant capacity of D-PAA, AgNPs/D-PAA and AuNPs/D-PAA. DNA cleavage, antimicrobial and biofilm inhibition effects of nanocomplexes were investigated. Nanocomplexes were found to be of moderate toxicity against fibroblasts with no genotoxicity observed. AgNPs/D-PAA reduced motility and proliferation at lower concentrations compared with the other studied nanomaterials. AgNPs/D-PAA and AuNPs/D-PAA showed radical scavenging capacities in a dose-dependent manner. The antimicrobial activity of AgNPs/D-PAA against various bacteria was found to be much higher compared to D-PAA and AuNPs/D-PAA, especially against E. hirae, E. faecalis and S. aureus, respectively. D-PAA, AgNPs/D-PAA and AuNPs/D-PAA showed DNA-cleaving and biofilm inhibitory activity, while AgNPs/D-PAA displayed the highest anti-biofilm activity. AgNPs/D-PAA and AuNPs/D-PAA were characterized by good antimicrobial activity. According to the findings of the study, AgNPs/D-PAA and AuNPs/D-PAA can be evaluated as alternatives for the preparation of new antimicrobial agents, the fight against biofilms, sterilization and disinfection processes. Our findings confirm the versatility of nanosystems based on dextran-polyacrylamide polymers and indicate that AgNPs/D-PAA and AuNPs/D-PAA can be evaluated as alternatives for the preparation of novel antimicrobial agents.en_US
dc.identifier.citationTkachenko, A., Özdemir, S., Tollu, G. , Antibacterial and antioxidant activity of gold and silver nanoparticles in dextran–polyacrylamide copolymers. Biometals 37, 115–130 (2024). https://doi.org/10.1007/s10534-023-00532-7en_US
dc.identifier.doi10.1007/s10534-023-00532-7en_US
dc.identifier.endpage130en_US
dc.identifier.issn0966-0844
dc.identifier.issn1572-8773
dc.identifier.issue1en_US
dc.identifier.pmid37651060en_US
dc.identifier.scopus2-s2.0-85169165436en_US
dc.identifier.startpage115en_US
dc.identifier.urihttps://hdl.handle.net/20.500.13099/329
dc.identifier.volume37en_US
dc.identifier.wos001062549100002en_US
dc.identifier.wosqualityQ2en_US
dc.institutionauthorOcak, Kasım
dc.language.isoengen_US
dc.publisherSpringer Linken_US
dc.relation.ispartofBioMetalsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAntimicrobial activityen_US
dc.subjectAntioxidanten_US
dc.subjectDNA cleavageen_US
dc.subjectGold nanoparticlesen_US
dc.subjectSilver nanoparticlesen_US
dc.titleAntibacterial and antioxidant activity of gold and silver nanoparticles in dextran–polyacrylamide copolymersen_US
dc.typearticleen_US

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