Central sensitization significantly deteriorates functionality and the interpretation of self-reported disease activity in primary Sjögren’s syndrome

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dc.contributor.authorSariyildiz, Aylin
dc.contributor.authorCoskun Benlidayi, Ilke
dc.contributor.authorYetişir, Ayşegül
dc.contributor.authorTurk, Ipek
dc.contributor.authorZengin Acemoglu, Serife Seyda
dc.contributor.authorDeniz, Volkan
dc.date.accessioned2025-03-17T12:22:45Z
dc.date.available2025-03-17T12:22:45Z
dc.date.issued2024
dc.departmentTarsus Üniversitesi
dc.description.abstractBackground: Central sensitization has a major role in health-related parameters in musculoskeletal conditions. There is still a lack of understanding regarding the impact of central sensitization on the interpretation of disease activity and functional disability in primary Sjögren’s syndrome (pSS). Methods: The Central Sensitization Inventory (CSI) was used to screen for central sensitization. Disease-related parameters, including objective tests, medication use, the EULAR SS Patient Reported Index (ESSPRI), and the EULAR SS Disease Activity Index (ESSDAI), were assessed. Functionality, quality of life, sleep, and mental health were evaluated by the Health Assessment Questionnaire-Disability Index (HAQ-DI), Medical Outcomes Study 36-Item Short Form Health Survey (SF-36), Jenkins Sleep Evaluation Scale (JSS), and Hospital Anxiety and Depression Scale (HADS), respectively. The effect of central sensitization on functionality and disease activity measures was assessed by regression analyses. Results: The frequency of central sensitization was 65% in patients with pSS (n = 60). Patients with central sensitization had higher HAQ-DI, ESSPRI, HADS, and JSS and lower SF-36 subdomain scores (p < 0.05 for all). A significant positive correlation was observed between the CSI score and the ESSPRI, JSS, HAQ-DI, and HADS scores (Spearman’s rho ranging from 0.342 to 0.739). The multiple regression analysis indicated that CSI was independently associated with HAQ-DI (adjusted R2 = 0.19, B = 0.01) and ESSPRI (adjusted R2 = 0.45, B = 0.08) (p < 0.001 for all). Conclusion: This study confirms that central sensitization has a major impact on functionality and the interpretation of self-reported disease activity in pSS. When devising strategies for the management of patients with pSS, it is crucial to consider these close relationships. (Table presented.) © The Author(s), under exclusive licence to International League of Associations for Rheumatology (ILAR) 2024.
dc.identifier.doi10.1007/s10067-024-06981-w
dc.identifier.endpage1958
dc.identifier.issn0770-3198
dc.identifier.issue6
dc.identifier.pmid38691249
dc.identifier.scopus2-s2.0-85192001881
dc.identifier.scopusqualityQ1
dc.identifier.startpage1949
dc.identifier.urihttps://doi.org/10.1007/s10067-024-06981-w
dc.identifier.urihttps://hdl.handle.net/20.500.13099/1343
dc.identifier.volume43
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringer Science and Business Media Deutschland GmbH
dc.relation.ispartofClinical Rheumatology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_Scopus_20250316
dc.subjectCentral sensitization
dc.subjectDisability
dc.subjectDisease activity
dc.subjectPsychological factors
dc.subjectQuality of life
dc.subjectSjögren’s syndrome
dc.titleCentral sensitization significantly deteriorates functionality and the interpretation of self-reported disease activity in primary Sjögren’s syndrome
dc.typeArticle

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