Exploration of Agrocybe aegerita mushroom polysaccharide-polyphenolic complex: Functional properties, binding efficiency, and biological activities

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dc.contributor.authorBains, Aarti
dc.contributor.authorGoksen, Gulden
dc.contributor.authorAli, Nemat
dc.contributor.authorKhan, Mohammad Rashid
dc.contributor.authorPatil, Sandip
dc.contributor.authorChawla, Prince
dc.date.accessioned2025-03-17T12:27:09Z
dc.date.available2025-03-17T12:27:09Z
dc.date.issued2025
dc.departmentTarsus Üniversitesi
dc.description.abstractThis study investigates the functional and biological activities of a polysaccharide-polyphenolic complex derived from the edible mushroom Agrocybe aegerita. Polyphenols were extracted using a modified solvent evaporation technique, and polysaccharides (AMP) were extracted using enzyme-assisted methods, yielding 8.02 %. The presence of fructose, mannose, glucose, galactose, sucrose, and maltose in varying amounts was confirmed. Different mushroom extracts concentrations (0.025-1.00 %) were tested for interaction with AMP. Samples with 0.2 % and 0.5 % extracts showed significantly higher binding efficiency with polysaccharides. AMP exhibited a particle size of 319 nm, while mushroom polysaccharide-polyphenolic compound complex (AMPP) revealed 136 nm with an irregular shape and smooth surface. Both AMP and AMPP showed three stages of decomposition, with distinct weight loss. Anti-quorum sensing tests against P. aeruginosa PAO1 showed that AMPP significantly decreased pyocyanin, pyoverdine, and swarming activity and exhibited higher biofilm inhibition. These findings suggest that the AMPP has substantial potential for developing sustainable health products, owing to its enhanced bioactivity.
dc.description.sponsorshipKing Saud University, Riyadh, Saudi Arabia [RSPD2025R713]
dc.description.sponsorshipSupport of Central Instrument Facility Lovely Professional University is greatly acknowledged. Also, the authors are thankful to the Re-searchers Supporting Project number (RSPD2025R713) , King Saud University, Riyadh, Saudi Arabia for supporting this study.
dc.identifier.doi10.1016/j.ijbiomac.2024.139309
dc.identifier.issn0141-8130
dc.identifier.issn1879-0003
dc.identifier.pmid39756726
dc.identifier.scopus2-s2.0-85214523317
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1016/j.ijbiomac.2024.139309
dc.identifier.urihttps://hdl.handle.net/20.500.13099/2098
dc.identifier.volume295
dc.identifier.wosWOS:001397233200001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier
dc.relation.ispartofInternational Journal of Biological Macromolecules
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20250316
dc.subjectAgrocybe aegerita
dc.subjectPolyphenols
dc.subjectPolysaccharides
dc.subjectAnti-quorum sensing
dc.subjectAntibiofilm
dc.subjectAnti-inflammatory
dc.titleExploration of Agrocybe aegerita mushroom polysaccharide-polyphenolic complex: Functional properties, binding efficiency, and biological activities
dc.typeArticle

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