Immunomodulatory activities of pH/temperature sensitive smart naringenin-loaded nanopolymers on the mammalian macrophages

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dc.contributor.authorYildirim, Metin
dc.contributor.authorAcet, Omur
dc.date.accessioned2025-03-17T12:27:27Z
dc.date.available2025-03-17T12:27:27Z
dc.date.issued2023
dc.departmentTarsus Üniversitesi
dc.description.abstractThis study aims to formulate naringenin (Nar)-loaded pH/temperature sensitive nanopolymers for therapeutic options for inflammatory diseases. For this aim, Nar loaded SNPs (NarSNPs) were synthesized by miniememulsion method and Scanning electron microscopy (SEM), Fourier-Transform Infrared Spectroscopy (FTIR) and, Dynamic Light Scattering (DLS) characterization experiments were conducted. The cytokines release (IL-6 and TNF-alpha) and cell viability were determined on lipopolysaccharide (LPS) induced RAW 264.7 macrophages. SNPs were determined as a potential naringenin carrier in terms of loading capacity, entrapment efficiency, pH/ temperature dependent release, and preservation of bioactivity of Nar. According to our cell viability analyses, NarSNPs are safe at concentration 120 mu g/mL. pH/temperature sensitive SNPs decreased the levels of the proinflammatory cytokines IL-6, TNF-alpha 3.95 and 4.35 times more efficiently than free Nar, respectively. These results indicate that SNPs increase bioactivity of Nar against adverse effects of inflammatory response.
dc.description.sponsorshipResearch Fund of Tarsus University in Turkey [SHMY.21.001]
dc.description.sponsorshipThis study was supported by the Research Fund of Tarsus University in Turkey with Project Number: SHMY.21.001. The authors would like to thank Ms. Harmony Matshik Dakafay for English language editing of the manuscript.
dc.identifier.doi10.1016/j.apsadv.2023.100527
dc.identifier.issn2666-5239
dc.identifier.scopus2-s2.0-85179114687
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1016/j.apsadv.2023.100527
dc.identifier.urihttps://hdl.handle.net/20.500.13099/2261
dc.identifier.volume18
dc.identifier.wosWOS:001128747500001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherElsevier
dc.relation.ispartofApplied Surface Science Advances
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20250316
dc.subjectNaringenin
dc.subjectSmart nanopolymers
dc.subjectTemperature sensitive polymer
dc.subjectpH sensitive polymer
dc.subjectRaw 264.7 cells
dc.titleImmunomodulatory activities of pH/temperature sensitive smart naringenin-loaded nanopolymers on the mammalian macrophages
dc.typeArticle

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