Pathophysiology of Circulating Biomarkers and Relationship With Vascular Aging: A Review of the Literature From VascAgeNet Group on Circulating Biomarkers, European Cooperation in Science and Technology Action 18216

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dc.authoridAcet, Omur/0000-0003-1864-5694
dc.authoridNavickas, Petras/0000-0002-0978-0571
dc.authoridSatrauskiene, Agne/0009-0004-8809-9355
dc.authoridZupkauskiene, Jurate/0000-0001-7031-0731
dc.authoridClimie, Rachel/0000-0002-7960-360X
dc.authoridFraenkel, Emil/0000-0002-3902-5067
dc.authoridGopcevic, Kristina/0000-0003-4045-6734
dc.contributor.authorGopcevic, Kristina R.
dc.contributor.authorGkaliagkousi, Eugenia
dc.contributor.authorNemcsik, Janos
dc.contributor.authorAcet, Omur
dc.contributor.authorBernal-Lopez, M. Rosa
dc.contributor.authorBruno, Rosa M.
dc.contributor.authorClimie, Rachel E.
dc.date.accessioned2025-03-17T12:25:18Z
dc.date.available2025-03-17T12:25:18Z
dc.date.issued2021
dc.departmentTarsus Üniversitesi
dc.description.abstractImpairment of the arteries is a product of sustained exposure to various deleterious factors and progresses with time; a phenomenon inherent to vascular aging. Oxidative stress, inflammation, the accumulation of harmful agents in high cardiovascular risk conditions, changes to the extracellular matrix, and/or alterations of the epigenetic modification of molecules, are all vital pathophysiological processes proven to contribute to vascular aging, and also lead to changes in levels of associated circulating molecules. Many of these molecules are consequently recognized as markers of vascular impairment and accelerated vascular aging in clinical and research settings, however, for these molecules to be classified as biomarkers of vascular aging, further criteria must be met. In this paper, we conducted a scoping literature review identifying thirty of the most important, and eight less important, biomarkers of vascular aging. Herein, we overview a selection of the most important molecules connected with the above-mentioned pathological conditions and study their usefulness as circulating biomarkers of vascular aging.
dc.description.sponsorshipCOST (European Cooperation in Science and Technology) [CA18216]
dc.description.sponsorshipFunding RC was supported by a Postdoctoral Fellowship from the National Heart Foundation of Australia (Award ID: 102484).
dc.identifier.doi10.3389/fphys.2021.789690
dc.identifier.issn1664-042X
dc.identifier.pmid34970157
dc.identifier.scopus2-s2.0-85121985029
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.3389/fphys.2021.789690
dc.identifier.urihttps://hdl.handle.net/20.500.13099/1605
dc.identifier.volume12
dc.identifier.wosWOS:000743901700001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherFrontiers Media Sa
dc.relation.ispartofFrontiers in Physiology
dc.relation.publicationcategoryDiğer
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20250316
dc.subjectvascular aging
dc.subjectcirculating biomarkers
dc.subjectoxidative stress
dc.subjectinflammation
dc.subjectcellular matrix
dc.subjectepigenetics
dc.titlePathophysiology of Circulating Biomarkers and Relationship With Vascular Aging: A Review of the Literature From VascAgeNet Group on Circulating Biomarkers, European Cooperation in Science and Technology Action 18216
dc.typeReview

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