Toxicity, Antibacterial, Antioxidant, Antidiabetic, and DNA Cleavage Effects of Dextran-Graft-Polyacrylamide/Zinc Oxide Nanosystems

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dc.authoridKutsevol, Nataliya/0000-0002-1468-4111
dc.authoridTkachenko, Anton/0000-0002-1029-1636
dc.contributor.authorYalcin, M. Serkan
dc.contributor.authorOzdemir, Sadin
dc.contributor.authorProkopiuk, Volodymyr
dc.contributor.authorVirych, Pavlo
dc.contributor.authorOnishchenko, Anatolii
dc.contributor.authorTollu, Gulsah
dc.contributor.authorPavlenko, Vadim
dc.date.accessioned2025-03-17T12:27:38Z
dc.date.available2025-03-17T12:27:38Z
dc.date.issued2024
dc.departmentTarsus Üniversitesi
dc.description.abstractSynthesis of metal oxide nanoparticles-polymer nanocomposites is an emerging strategy in nanotechnology to improve targeted delivery and reduce the toxicity of nanoparticles. In this study, we report biological effects of previously described hybrid nanocomposites containing dextran-graft-polyacrylamide/zinc oxide nanoparticles (D-PAA/ZnO NPs) prepared from zinc sulfate (D-PAA/ZnONPs(SO42-)) and zinc acetate (D-PAA/ZnONPs(-OAc)) focusing primarily on their antimicrobial activity. D-PAA/ZnONPs(SO42-) and D-PAA/ZnONPs(-OAc) nanosystems were tested in a complex way to assess their antioxidant activity (DPPH assay), antidiabetic potential (alpha-amylase inhibition), DNA cleavage activity, antimicrobial, and antibiofilm activity. In addition, the toxicity of D-PAA/ZnONPs(SO42-) and D-PAA/ZnONPs(-OAc) nanosystems against primary murine splenocytes was tested using MTT assay. The studied nanosystems inhibited E.coli growth. For all the investigated strains, minimum inhibitory concentrations (MICs) of D-PAA/ZnONPs(SO42-) and D-PAA/ZnONPs(-OAc) were in the range of 8 mg/L-128 mg/L and 16 mg/L-128 mg/L, respectively. The nanocomposites demonstrated effective antibiofilm properties as 94.27% and 86.43%. The compounds showed good antioxidant, anti-alpha-amylase, and DNA cleavage activities. D-PAA/ZnONPs(SO42-) and D-PAA/ZnONPs(-OAc) nanosystems reduced cell viability and promoted cell death of primary murine spleen cells at concentrations higher than those that proved to be antibacterial indicating the presence of therapeutic window. D-PAA/ZnONPs(SO42-) and D-PAA/ZnONPs(-OAc) nanosystems show antioxidant, antidiabetic, DNA cleavage, antimicrobial, and antibiofilm activity against the background of good biocompatibility suggesting the presence of therapeutic potential, which should be further investigated in vivo.
dc.description.sponsorshipNational Research Foundation of Ukraine [2021.01/0414, 0123U102126]
dc.description.sponsorshipThis research was partly supported by the Grant of the National Research Foundation of Ukraine (project & numero; 2021.01/0414 and & numero; 0123U102126).
dc.identifier.doi10.1007/s00284-024-03953-w
dc.identifier.issn0343-8651
dc.identifier.issn1432-0991
dc.identifier.issue12
dc.identifier.pmid39487865
dc.identifier.scopus2-s2.0-85208291806
dc.identifier.scopusqualityQ3
dc.identifier.urihttps://doi.org/10.1007/s00284-024-03953-w
dc.identifier.urihttps://hdl.handle.net/20.500.13099/2372
dc.identifier.volume81
dc.identifier.wosWOS:001346183800003
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringer
dc.relation.ispartofCurrent Microbiology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20250316
dc.subjectAntimicrobial Activity
dc.subjectZno Nanoparticles
dc.subjectZinc
dc.subjectBiosynthesis
dc.subjectTherapy
dc.subjectGrowth
dc.titleToxicity, Antibacterial, Antioxidant, Antidiabetic, and DNA Cleavage Effects of Dextran-Graft-Polyacrylamide/Zinc Oxide Nanosystems
dc.typeArticle

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