Antifungal photodynamic activities of phthalocyanine derivatives on Candida albicans

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dc.authoridInce, Mine/0000-0002-9164-0446
dc.authoridOZTURK, ISMAIL/0000-0002-2669-3090
dc.authoridTuncel, Ayca/0000-0003-0699-3309
dc.authoridYurt, Fatma/0000-0002-9394-6908
dc.contributor.authorOzturk, Ismail
dc.contributor.authorTuncel, Ayca
dc.contributor.authorYurt, Fatma
dc.contributor.authorBiyiklioglu, Zekeriya
dc.contributor.authorInce, Mine
dc.contributor.authorOcakoglu, Kasim
dc.date.accessioned2025-03-17T12:26:01Z
dc.date.available2025-03-17T12:26:01Z
dc.date.issued2020
dc.departmentTarsus Üniversitesi
dc.description.abstractAntimicrobial resistance is one of the most important causes of morbidity and mortality in the treatment of infectious diseases worldwide. Candida albicans is one of the most virulent and common species of fungi to cause invasive fungal infections on humans. Alternative treatment strategies, including photodynamic therapy, are needed for controlling these infectious diseases. The aim of this study was to investigate the antifungal photodynamic activities of phthalocyanine derivatives on C. albicans. The minimum inhibitory concentration (MIC) values of compounds were determined by the broth microdilution method. Uptake of the compounds in C. albicans and dark toxicity of the compounds were also investigated. Photodynamic inhibition of growth experiments was performed by measuring the colony-forming unit/mL (CFU/mL) of the strain. Maximum uptake into the cells was observed in the presence of 64 mu g/mL concentration for each compound except for ZnPc. Compounds did not show dark toxicity/inhibitory effects at sub-MIC concentrations on C. albicans when compared to the negative control groups. Zn(II)Pc, ZnPc, and ZnPc-TiO2 showed fungicidal effect after irradiation with the light dose of 90 J/cm(2) in the presence of the compounds. In addition to the fungicidal effects, SubPc, SubPc-TiO2, Es-SiPc, and Es-SubPc compounds were also found to have inhibitory effects on the growth of yeast cells after irradiation.
dc.description.sponsorshipEge University Scientific Research Projects (BAP) commission [18 NBE 003]
dc.description.sponsorshipThis work was supported by Ege University Scientific Research Projects (BAP) commission with 18 NBE 003 project code.
dc.identifier.doi10.1016/j.pdpdt.2020.101715
dc.identifier.issn1572-1000
dc.identifier.issn1873-1597
dc.identifier.pmid32165338
dc.identifier.scopus2-s2.0-85082737102
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1016/j.pdpdt.2020.101715
dc.identifier.urihttps://hdl.handle.net/20.500.13099/1991
dc.identifier.volume30
dc.identifier.wosWOS:000540895900057
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier
dc.relation.ispartofPhotodiagnosis and Photodynamic Therapy
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20250316
dc.subjectPhthalocyanine
dc.subjectAntifungal photodynamic activity
dc.subjectPhotodynamic therapy
dc.subjectC. albicans
dc.titleAntifungal photodynamic activities of phthalocyanine derivatives on Candida albicans
dc.typeArticle

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