Synthesis of Rhombic Dodecahedral Cuprous Oxide Nanoparticles and Investigation of Biological Activity

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dc.authoridISIK, Zelal/0000-0002-1249-8550
dc.contributor.authorKucukosman, Ridvan
dc.contributor.authorIsik, Zelal
dc.contributor.authorOzdemir, Sadin
dc.contributor.authorGonca, Serpil
dc.contributor.authorOcakoglu, Kasim
dc.contributor.authorDizge, Nadir
dc.date.accessioned2025-03-17T12:27:29Z
dc.date.available2025-03-17T12:27:29Z
dc.date.issued2022
dc.departmentTarsus Üniversitesi
dc.description.abstractThe rhombic dodecahedral cuprous oxide (Cu2O) nanoparticles (NPs) were synthesized with the morphology-controlled one-pot solution-phase technique and several biological activities were investigated. The structural and elemental properties of Cu2O NPs were determined by SEM-EDX and XRD. Antioxidant, antimicrobial, DNA interaction, and biofilm inhibition activities were determined by using DPPH radical scavenging and metal chelating, microdilution, agarose gel electrophoresis, and crystal violet methods, respectively. The newly synthesized copper nanoparticle showed excellent DPPH and iron-chelating activities as 100% at 200 mg/L concentration. It showed good DNA cleavage activity at all concentrations. Cu2O NP had good antibacterial activity against all tested microorganisms. Biofilm inhibition percentage of Cu2O NP was determined as 86.3% at 500 mg/L. The cell viability assay demonstrated that the Cu2O NP showed 100% cell viability inhibition at all concentrations. Generally, owing to the biological active nature of the synthesized copper nanoparticle, these synthesized Cu2O NPs can be used as a therapeutic and antioxidant agent.
dc.identifier.doi10.1007/s12668-022-00995-x
dc.identifier.endpage813
dc.identifier.issn2191-1630
dc.identifier.issn2191-1649
dc.identifier.issue3
dc.identifier.scopus2-s2.0-85130755541
dc.identifier.scopusqualityQ2
dc.identifier.startpage804
dc.identifier.urihttps://doi.org/10.1007/s12668-022-00995-x
dc.identifier.urihttps://hdl.handle.net/20.500.13099/2283
dc.identifier.volume12
dc.identifier.wosWOS:000805468700001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherSpringer
dc.relation.ispartofBionanoscience
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20250316
dc.subjectCopper oxide nanoparticle
dc.subjectAntioxidant
dc.subjectDNA cleavage
dc.subjectAntimicrobial
dc.titleSynthesis of Rhombic Dodecahedral Cuprous Oxide Nanoparticles and Investigation of Biological Activity
dc.typeArticle

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