Synthesis of Rhombic Dodecahedral Cuprous Oxide Nanoparticles and Investigation of Biological Activity
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Tarih
2022
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Springer
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
The rhombic dodecahedral cuprous oxide (Cu2O) nanoparticles (NPs) were synthesized with the morphology-controlled one-pot solution-phase technique and several biological activities were investigated. The structural and elemental properties of Cu2O NPs were determined by SEM-EDX and XRD. Antioxidant, antimicrobial, DNA interaction, and biofilm inhibition activities were determined by using DPPH radical scavenging and metal chelating, microdilution, agarose gel electrophoresis, and crystal violet methods, respectively. The newly synthesized copper nanoparticle showed excellent DPPH and iron-chelating activities as 100% at 200 mg/L concentration. It showed good DNA cleavage activity at all concentrations. Cu2O NP had good antibacterial activity against all tested microorganisms. Biofilm inhibition percentage of Cu2O NP was determined as 86.3% at 500 mg/L. The cell viability assay demonstrated that the Cu2O NP showed 100% cell viability inhibition at all concentrations. Generally, owing to the biological active nature of the synthesized copper nanoparticle, these synthesized Cu2O NPs can be used as a therapeutic and antioxidant agent.
Açıklama
Anahtar Kelimeler
Copper oxide nanoparticle, Antioxidant, DNA cleavage, Antimicrobial
Kaynak
Bionanoscience
WoS Q Değeri
N/A
Scopus Q Değeri
Q2
Cilt
12
Sayı
3
