Evaluation of photodynamic therapy and nuclear imaging potential of subphthalocyanine integrated TiO 2 nanoparticles in mammary and cervical tumor cells

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dc.contributor.authorYurt, Fatma
dc.contributor.authorOcakoglu, Kasim
dc.contributor.authorEr, Ozge
dc.contributor.authorSoylu, Hale Melis
dc.contributor.authorInce, Mine
dc.contributor.authorAvci, Clglr Biray
dc.contributor.authorKurt, Cansu Caliskan
dc.date.accessioned2025-03-17T12:22:52Z
dc.date.available2025-03-17T12:22:52Z
dc.date.issued2019
dc.departmentTarsus Üniversitesi
dc.description.abstractThis study, subphthalocyanines (SubPc) and SubPc integrated TiO2 nanoparticles (SubPc-TiO2) were synthesized as novel photosensitizers. Their PDT effects were evaluated. Furthermore, nuclear imaging potential of 131I-labelled SubPc/SubPc-TiO2 were examined in mouse mammary carcinoma (EMT6) and cervix adenocarcinoma (HeLa) cell lines. The uptake results show that SubPc labelled with 131I radionuclide (131I-SubPc) in EMT6 and HeLa cell lines was found to be approximately the same as in the WI38 cell line. However, the uptake values of SubPc-TiO2 labelled with 131I (131I-SubPc-TiO2) in EMT6 and HeLa cell lines were determined to be two times higher than in the WI38 cell line. In other words, the target/non-target tissue ratio was identified as two in the EMT6 and HeLa cell lines. 131I-SubPc-TiO2 is promising for imaging or treatment of breast and cervix tumors. In vitro photodynamic therapy studies have shown that SubPc and SubPc-TiO2 are suitable agents for PDT. In addition, SubPc-TiO2 has higher phototoxicity than SubPc. As a future study, in vivo experiments will be held and performed in tumor-bearing nude mice. © 2019 World Scientific Publishing Company.
dc.description.sponsorshipTUBITAK, (114Z430)
dc.description.sponsorshipTürkiye Bilimsel ve Teknolojik Araştirma Kurumu, TÜBITAK
dc.identifier.doi10.1142/S1088424619500639-2
dc.identifier.endpage915
dc.identifier.issn1088-4246
dc.identifier.issue7-8
dc.identifier.scopus2-s2.0-85067170832
dc.identifier.scopusqualityQ3
dc.identifier.startpage908
dc.identifier.urihttps://doi.org/10.1142/S1088424619500639-2
dc.identifier.urihttps://hdl.handle.net/20.500.13099/1427
dc.identifier.volume23
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherWorld Scientific Publishing Co. Pte Ltd
dc.relation.ispartofJournal of Porphyrins and Phthalocyanines
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_Scopus_20250316
dc.subjectnuclear imaging
dc.subjectphotodynamic therapy
dc.subjectsubphthalocyanine
dc.subjecttitanium nanoparticle
dc.titleEvaluation of photodynamic therapy and nuclear imaging potential of subphthalocyanine integrated TiO 2 nanoparticles in mammary and cervical tumor cells
dc.typeArticle

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