Evaluation of photodynamic therapy and nuclear imaging potential of subphthalocyanine integrated TiO 2 nanoparticles in mammary and cervical tumor cells
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Tarih
2019
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
World Scientific Publishing Co. Pte Ltd
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
This study, subphthalocyanines (SubPc) and SubPc integrated TiO2 nanoparticles (SubPc-TiO2) were synthesized as novel photosensitizers. Their PDT effects were evaluated. Furthermore, nuclear imaging potential of 131I-labelled SubPc/SubPc-TiO2 were examined in mouse mammary carcinoma (EMT6) and cervix adenocarcinoma (HeLa) cell lines. The uptake results show that SubPc labelled with 131I radionuclide (131I-SubPc) in EMT6 and HeLa cell lines was found to be approximately the same as in the WI38 cell line. However, the uptake values of SubPc-TiO2 labelled with 131I (131I-SubPc-TiO2) in EMT6 and HeLa cell lines were determined to be two times higher than in the WI38 cell line. In other words, the target/non-target tissue ratio was identified as two in the EMT6 and HeLa cell lines. 131I-SubPc-TiO2 is promising for imaging or treatment of breast and cervix tumors. In vitro photodynamic therapy studies have shown that SubPc and SubPc-TiO2 are suitable agents for PDT. In addition, SubPc-TiO2 has higher phototoxicity than SubPc. As a future study, in vivo experiments will be held and performed in tumor-bearing nude mice. © 2019 World Scientific Publishing Company.
Açıklama
Anahtar Kelimeler
nuclear imaging, photodynamic therapy, subphthalocyanine, titanium nanoparticle
Kaynak
Journal of Porphyrins and Phthalocyanines
WoS Q Değeri
Scopus Q Değeri
Q3
Cilt
23
Sayı
7-8
