Photo induced anti-inflammatory activities of a Thiophene substituted subphthalocyanine derivative

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dc.authoridAYAZ, FURKAN/0000-0003-0271-0594
dc.authoridYUZER, ABDULCELIL/0000-0002-2287-4126
dc.authoridInce, Mine/0000-0002-9164-0446
dc.authoridTOPAL ONAL, Harika/0000-0002-7466-2942
dc.contributor.authorOnal, Harika Topal
dc.contributor.authorYuzer, Abdulcelil
dc.contributor.authorInce, Mine
dc.contributor.authorAyaz, Furkan
dc.date.accessioned2025-03-17T12:26:01Z
dc.date.available2025-03-17T12:26:01Z
dc.date.issued2020
dc.departmentTarsus Üniversitesi
dc.description.abstractMaterials that possess photo induced biological activities present opportunities for more localized, targeted and efficient treatment options that may also reduce side effects. There have been studies supporting photo induced effects of photosensitizers as anti-cancer, anti-inflammatory and anti-microbial agents. In this study, we tested photo activated anti-inflammatory effects of a Thiophene substituted subphthalocyanine (SubPc) derivative. Thiophene and its derivatives are well known for their anti-inflammatory and anti-microbial effects. There are unwanted side effects associated with Thiophene derivatives. By substituting this biologically active molecule to SubPc structure we acquired control over its activation. Upon light treatment this derivative exerted anti-inflammatory activity on the mammalian macrophages in vitro based on the substantial decrease in extracellular inflammatory cytokine levels. Our results suggest that Thiophene substituted SubPc derivative has photo induced anti-inflammatory activities. This material can be used for the treatment of patients suffering from chronic inflammation that are not associated with a bacterial burden such as autoimmune diseases and inflammatory or allergic reactions.
dc.identifier.doi10.1016/j.pdpdt.2020.101701
dc.identifier.issn1572-1000
dc.identifier.issn1873-1597
dc.identifier.pmid32184175
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1016/j.pdpdt.2020.101701
dc.identifier.urihttps://hdl.handle.net/20.500.13099/1992
dc.identifier.volume30
dc.identifier.wosWOS:000540895900044
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier
dc.relation.ispartofPhotodiagnosis and Photodynamic Therapy
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20250316
dc.subjectMacrophages
dc.subjectInflammation
dc.subjectAnti-microbial activity
dc.subjectPDT
dc.subjectSubphthalocyanine
dc.subjectThiophene
dc.titlePhoto induced anti-inflammatory activities of a Thiophene substituted subphthalocyanine derivative
dc.typeArticle

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