Psychobiotics for Mitigation of Neuro-Degenerative Diseases: Recent Advancements

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dc.authoridDuhan, Joginder Singh/0000-0001-5089-4442
dc.authoridGoksen, Gulden/0000-0002-5432-7936
dc.authoridDhull, Sanju Bala/0000-0002-5749-6241
dc.contributor.authorDhyani, Priya
dc.contributor.authorGoyal, Chhaya
dc.contributor.authorDhull, Sanju Bala
dc.contributor.authorChauhan, Anil Kumar
dc.contributor.authorSaharan, Baljeet Singh
dc.contributor.authorHarshita
dc.contributor.authorDuhan, Joginder Singh
dc.date.accessioned2025-03-17T12:27:42Z
dc.date.available2025-03-17T12:27:42Z
dc.date.issued2024
dc.departmentTarsus Üniversitesi
dc.description.abstractAgeing is inevitable and poses a universal challenge for all living organisms, including humans. The human body experiences rapid cell division and metabolism until approximately 25 years of age, after which the accumulation of metabolic by-products and cellular damage leads to age-related diseases. Neurodegenerative diseases are of concern due to their irreversible nature, lack of effective treatment, and impact on society and the economy. Researchers are interested in finding drugs that can effectively alleviate ageing and age-related diseases without side-effects. Psychobiotics are a novel class of probiotic organisms and prebiotic interventions that confer mental health benefits to the host when taken appropriately. Psychobiotic strains affect functions related to the central nervous system (CNS) and behaviors mediated by the Gut-Brain-Axis (GBA) through various pathways. There is an increasing interest in researchers of these microbial-based psychopharmaceuticals. Psychobiotics have been reported to reduce neuronal ageing, inflammation, oxidative stress, and cortisol levels; increase synaptic plasticity and levels of neurotransmitters and antioxidants. The present review focuses on the manifestation of elderly neurodegenerative and mental disorders, particularly Alzheimer's disease (AD), Parkinson's disease (PD), and depression, and the current status of their potential alleviation through psychobiotic interventions, highlighting their possible mechanisms of action. Psychobiotics represent a category of probiotics that exert positive effects on mental health by influencing the Gut-Brain-Axis. Their mechanism involves modulation of the immune system, hypothalamic-pituitary-axis, and neurotransmitter production. In this review, the impact of different psychobiotics on mental well-being is explored and also their potential as an alternative therapy for neurodegenerative and mental disorders. image
dc.description.sponsorshipSeed Grant Development Scheme [3254]; UGC, GoI
dc.description.sponsorshipAuthors acknowledge the funding from Seed Grant Development Scheme 6031 (PFMS no 3254) provided by UGC, GoI, under the Institution of Eminence Scheme to Banaras Hindu University, Varanasi, India.
dc.identifier.doi10.1002/mnfr.202300461
dc.identifier.issn1613-4125
dc.identifier.issn1613-4133
dc.identifier.issue13
dc.identifier.pmid37715243
dc.identifier.scopus2-s2.0-85171169364
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1002/mnfr.202300461
dc.identifier.urihttps://hdl.handle.net/20.500.13099/2399
dc.identifier.volume68
dc.identifier.wosWOS:001065903800001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofMolecular Nutrition & Food Research
dc.relation.publicationcategoryDiğer
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20250316
dc.subjectbenefits
dc.subjecthealth
dc.subjectneuro-degenerative diseases
dc.subjectprobiotic organisms
dc.subjectprebiotics
dc.subjectpsychobiotics
dc.titlePsychobiotics for Mitigation of Neuro-Degenerative Diseases: Recent Advancements
dc.typeReview

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