Green synthesis of 2-amino-3-cyanopyridines via a cooperative vinylogous anomeric-based oxidation and their antiproliferative effects on liver, breast, and prostate cancer studies

Basit Öğe Kaydı
dc.authoridErsatir, Mehmet/0000-0003-1077-0626
dc.contributor.authorErsatir, Mehmet
dc.contributor.authorYildirim, Metin
dc.date.accessioned2025-03-17T12:25:49Z
dc.date.available2025-03-17T12:25:49Z
dc.date.issued2021
dc.departmentTarsus Üniversitesi
dc.description.abstract2-Amino-3-cyanopyridine derivatives were synthesized in an ultrasonic bath and one pot four-component reactions with high yields, in a short time, without solvent and catalyst, and anticancer activity studies on MCF7, DU145, and HepG2 cell lines were investigated. 18 compounds were synthesized in 4-25 min time interval and 85-99% yield. Among these compounds, the IC50 values in 7a, 6a, and 3a on MCF7 breast cancer cell line was found to be 1.80, 1.95, and 2.50 mu M, respectively, while the values in the HepG2 liver cancer cell line were 7.71, 7.90, and 8.05 mu M, respectively. In studies conducted in the DU145 prostate cancer cell line, IC50 values of compounds 1b, 2b, and 8b were found to be 9.90, 10.10, and 15.30 mu M, respectively.
dc.description.sponsorshipScientific and Technical Research Council of Turkey (TUBITAK)
dc.description.sponsorshipThe authors are greatly thankful to the Scientific and Technical Research Council of Turkey (TUBITAK) for a scholarship to Mehmet Eratr.
dc.identifier.doi10.1080/00397911.2021.1878537
dc.identifier.endpage1265
dc.identifier.issn0039-7911
dc.identifier.issn1532-2432
dc.identifier.issue8
dc.identifier.scopus2-s2.0-85100238862
dc.identifier.scopusqualityQ2
dc.identifier.startpage1252
dc.identifier.urihttps://doi.org/10.1080/00397911.2021.1878537
dc.identifier.urihttps://hdl.handle.net/20.500.13099/1893
dc.identifier.volume51
dc.identifier.wosWOS:000613813600001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherTaylor & Francis Inc
dc.relation.ispartofSynthetic Communications
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20250316
dc.subjectAminocyanopyridine
dc.subjectultrasonic irradiation
dc.subjectmulticomponent reaction
dc.subjectheterocycles
dc.subjectanticancer activity
dc.subjectprostate cancer
dc.subjectbreast cancer
dc.subjectliver cancer
dc.titleGreen synthesis of 2-amino-3-cyanopyridines via a cooperative vinylogous anomeric-based oxidation and their antiproliferative effects on liver, breast, and prostate cancer studies
dc.typeArticle

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu