Green synthesis of 2-amino-3-cyanopyridines via a cooperative vinylogous anomeric-based oxidation and their antiproliferative effects on liver, breast, and prostate cancer studies
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Tarih
2021
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Taylor & Francis Inc
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
2-Amino-3-cyanopyridine derivatives were synthesized in an ultrasonic bath and one pot four-component reactions with high yields, in a short time, without solvent and catalyst, and anticancer activity studies on MCF7, DU145, and HepG2 cell lines were investigated. 18 compounds were synthesized in 4-25 min time interval and 85-99% yield. Among these compounds, the IC50 values in 7a, 6a, and 3a on MCF7 breast cancer cell line was found to be 1.80, 1.95, and 2.50 mu M, respectively, while the values in the HepG2 liver cancer cell line were 7.71, 7.90, and 8.05 mu M, respectively. In studies conducted in the DU145 prostate cancer cell line, IC50 values of compounds 1b, 2b, and 8b were found to be 9.90, 10.10, and 15.30 mu M, respectively.
Açıklama
Anahtar Kelimeler
Aminocyanopyridine, ultrasonic irradiation, multicomponent reaction, heterocycles, anticancer activity, prostate cancer, breast cancer, liver cancer
Kaynak
Synthetic Communications
WoS Q Değeri
Q3
Scopus Q Değeri
Q2
Cilt
51
Sayı
8
