Immunomodulatory activities of zinc(II)phthalocyanine on the mammalian macrophages through p38 pathway: Potential ex vivo immunomodulatory PDT reagents

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dc.authoridInce, Mine/0000-0002-9164-0446
dc.authoridAYAZ, FURKAN/0000-0003-0271-0594
dc.authoridYUZER, ABDULCELIL/0000-0002-2287-4126
dc.contributor.authorYuzer, Abdulcelil
dc.contributor.authorAyaz, Furkan
dc.contributor.authorInce, Mine
dc.date.accessioned2025-03-17T12:27:26Z
dc.date.available2025-03-17T12:27:26Z
dc.date.issued2019
dc.departmentTarsus Üniversitesi
dc.description.abstractA series of zinc phthalocyanine having imidazolyl moieties was synthesized. These compounds' immunostimulatory and immunomodulatory activities were tested on the mammalian macrophages in vitro. In the absence of photo induction neither dmso soluble nor the water soluble imidazole Pc had any immunostimulatory or immunomodulatory effect on the macrophage activity based on the differences in the pro-inflammatory cytokine secretion levels compared to the control groups. Upon photo induction, especially, at 5 min exposure time both derivatives lead to an increased pro-inflammatory cytokine secretion level by LPS activated macrophages. Whereas, this effect was completely reversed after 10 min of light treatment and both derivatives gained stark anti-inflammatory potential. Our molecules were cell penetrating and exerted their effects by regulating the phosphorylation levels of p38. This study is one of its first examples suggesting differential immunomodulatory photo dynamic therapy applications of phthalocyanine derivatives depending on light exposure time as well as their possible route of modulating the intracellular signaling pathways.
dc.identifier.doi10.1016/j.bioorg.2019.103249
dc.identifier.issn0045-2068
dc.identifier.issn1090-2120
dc.identifier.pmid31539741
dc.identifier.scopus2-s2.0-85072209968
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1016/j.bioorg.2019.103249
dc.identifier.urihttps://hdl.handle.net/20.500.13099/2251
dc.identifier.volume92
dc.identifier.wosWOS:000489699400050
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherAcademic Press Inc Elsevier Science
dc.relation.ispartofBioorganic Chemistry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20250316
dc.subjectPhthalocyanines
dc.subjectMacrophages
dc.subjectAnti-inflammatory molecules
dc.subjectImmunomodulation
dc.subjectPDT
dc.titleImmunomodulatory activities of zinc(II)phthalocyanine on the mammalian macrophages through p38 pathway: Potential ex vivo immunomodulatory PDT reagents
dc.typeArticle

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