Synthesis, characterization and anticancer effect of doxorubicin-loaded dual stimuli-responsive smart nanopolymers

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dc.authoridShcharbin, Dzmitry/0000-0002-1414-4465
dc.authoridAcet, Omur/0000-0003-1864-5694
dc.contributor.authorAcet, Omur
dc.contributor.authorKirsanov, Pavel
dc.contributor.authorAcet, Burcu Onal
dc.contributor.authorHalets-Bui, Inessa
dc.contributor.authorShcharbin, Dzmitry
dc.contributor.authorComert, Seyda Ceylan
dc.contributor.authorOdabasi, Mehmet
dc.date.accessioned2025-03-17T12:25:11Z
dc.date.available2025-03-17T12:25:11Z
dc.date.issued2024
dc.departmentTarsus Üniversitesi
dc.description.abstractNanopolymers represent a significant group of delivery vehicles for hydrophobic drugs. In particular, dual stimuli-responsive smart polymer nanomaterials might be extremely useful for drug delivery and release. We analyzed the possibility to include the known antitumor drug doxorubicin (DOX), which has antimitotic and antiproliferative effects, in a nanopolymer complex. Thus, doxorubicin-loaded temperature- and pH-sensitive smart nanopolymers (DOX-SNPs) were produced. Characterizations of the synthesized nanostructures were carried out including zeta potential measurements, Fourier-transform infrared spectroscopy, and scanning electron microscopy. The loading capacity of the nanopolymers for DOX was investigated, and encapsulation and release studies were carried out. In a final step, the cytotoxicity of the DOX-nanopolymer complexes against the HeLa cancer cell line at different concentrations and incubation times was studied. The DOX release depended on temperature and pH value of the release medium, with the highest release at pH 6.0 and 41 degrees C. This effect was similar to that observed for the commercial liposomal formulation of doxorubicin Doxil. The obtained results demonstrated that smart nanopolymers can be efficiently used to create new types of doxorubicin-based drugs.
dc.identifier.doi10.3762/bjnano.15.96
dc.identifier.endpage1196
dc.identifier.issn2190-4286
dc.identifier.pmid39355301
dc.identifier.scopus2-s2.0-85213282105
dc.identifier.scopusqualityQ1
dc.identifier.startpage1189
dc.identifier.urihttps://doi.org/10.3762/bjnano.15.96
dc.identifier.urihttps://hdl.handle.net/20.500.13099/1542
dc.identifier.volume15
dc.identifier.wosWOS:001327393000001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherBeilstein-Institut
dc.relation.ispartofBeilstein Journal of Nanotechnology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20250316
dc.subjectcancer cell line HeLa
dc.subjectcytotoxicity
dc.subjectdoxorubicin
dc.subjectdrug delivery
dc.subjectsmart nanopolymers
dc.subjecttemperature- and pH-sensitive nanopolymer
dc.titleSynthesis, characterization and anticancer effect of doxorubicin-loaded dual stimuli-responsive smart nanopolymers
dc.typeArticle

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